Summary
Angiography under experimental conditions shows that Urografin has a vasodilator action of the order of 8% upon the basal cerebral arteries of the baboon. This action is not seen within the first 4 sec of the angiogram and the dilator effect of a single injection has passed off completely 15 min later. Three successive injections within 7 min show little evidence of cumulative vasodilatation. The vasodilator action of three successive angiograms has disappeared 22 to 29 min later. Because of wide variations in the degree of vasodilatation shown by individual baboons it may be necessary to use each baboon as its own control in subsequent work.
Résumé
L'angiographie cerebrale realisée dans des conditions experimentales présente un effet vasodilatoire d'environ 8% sur les artères basales du babouin. Cette action n'apparait pas durant les 4 premières sec, et l'effet dilatoire d'une injection isolée est totalement effacé après 15 min. Trois injections successives realisées en 7 min ne montrent pas d'effet cumulatif important. La vasodilatation entrainée par trois angiographies successives est effacée après 22 a 29 min. En raison des variations importantes dans le degré de vasodilatation d'un animal à l'autre il est preferable d'utiliser chaque singe comme son propre controle.
Zusammenfassung
Der vasodilatatorische Effekt von Urographin auf die Hauptarterien des Hirns des Pavians wird gezeigt. Das Ausmaß beträgt ca. 8%; dieser Wert wird durch Ausmessen des Durchmessers angiographisch dargestellter Arterien gewonnen. Nach einer Einzelinjektion von Urographin tritt eine Vasodilatation erst 4 sec nach Injektionsbeginn auf und bleibt ca. 15 min bestehen. Rasch aufeinanderfolgende Injektionen (3 innerhalb 7 min) zeigen keinen potenzierenden Effekt. Die Vasodilatation bildet sich nach 22 bis 29 min zurück.
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A mixture of sodium and meglumine diatrizoate in the proportion of 1:6.6
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du Boulay, G., Kendall, B.E., Symon, L. et al. The vasodilator action of angiography with Urografin* 60% on the basal vessels of the brain of the baboon. Neuroradiology 9, 133–137 (1975). https://doi.org/10.1007/BF00332961
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DOI: https://doi.org/10.1007/BF00332961