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Segregation of mitochondrially inherited antibiotic resistance genes in zygote cell lineages of Saccharomyces cerevisiae

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Summary

An analysis of cell lineages from individual zygotes derived from crosses involving two mitochondrial antibiotic resistance genes suggests that

  1. (i)

    the parental mating type of a strain can influence the transmission of mitochondrial genes;

  2. (ii)

    different genes can vary in the proportion of zygote daughters which are “homozygous” for this gene;

  3. (iii)

    the particular genotypes included in a zygote daughter are related to the position at which this daughter is budded from the zygote;

  4. (iv)

    recombination between mitochondrial DNA molecules is restricted to the zygote.

The segregation and recombination of mitochondrial genes is discussed in relation to the possile distribution of mitochondrial DNA during budding of zygotes and zygote daughters.

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References

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Author information

Authors and Affiliations

  1. Department of Genetics, University of Adelaide, South Australia

    David F. Callen

Authors
  1. David F. Callen
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Additional information

Communicated by F. Kaudewitz

This work was supported by a University of Adelaide Research Grant. The spiramycin was a gift from May and Baker Pty. Ltd., Adelaide.

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Callen, D.F. Segregation of mitochondrially inherited antibiotic resistance genes in zygote cell lineages of Saccharomyces cerevisiae . Molec. gen. Genet. 134, 65–76 (1974). https://doi.org/10.1007/BF00332813

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  • DOI: https://doi.org/10.1007/BF00332813

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