Summary
In this paper we describe the meiotic pairing behavior of two free duplications in Caenorhabditis elegans. sDp1 is a duplication of approximately 30 map units of the right portion of linkage group I including unc-74 to unc-54. This duplication pairs, recombines, and apparently segregates from one of the normal homologues. A second duplication, sDp2, is a duplication of approximately 15 map units of the left portion of the linkage group. sDp2 was not observed to recombine with the normal homologue but did suppress exchange between the two normal homologues in a sDp2/ ++ / dpy-5 unc-35 heterozygote. Although a number of free duplications have been described previously in Caenorhabditis elegans, none of these have been shown to pair with normal homologues. The meiotic behavior of the duplications described in this paper can be understood assuming the existence in C. elegans chromosomes of pairing sites of the type described in D. melanogaster chromosomes (I. Sandler 1956; Hawley 1980).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71–94
Clarke L, Carbon J (1983) Genomic substitutions of centromeres in Saccharomyces cerevisiae. Nature 287:504–509
Grell RF (1976) Distributive pairing. In: Ashburner M, Novitski E (eds) The genetics and biology of Drosophila, vol Ia. Academic Press, New York, pp 436–486
Hawley RS (1980) Chromosomal sites necessary for normal levels of meiotic recombination in Drosophila melanogaster: I. Evidence for and mapping of the sites. Genetics 94:625–646
Herman RK, Albertson DG, Brenner S (1976) Chromosome rearrangements in Caenorhabditis elegans. Genetics 83:91–105
Herman RK, Kari CK, Hartman PS (1982) Dominant X-chromosome nondisjunction mutants of Caenorhabditis elegans. Genetics 102:379–400
Herman RK, Madl JE, Kari CK (1979) Duplications in Caenorhabditis elegans. Genetics 92:419–435
Hodgkin JA (1974) Genetic and anatomical aspects of the Caenorhabditis male. Ph.D. thesis, University of Cambridge, England
Hodgkin J (1980) More sex-determination mutants of Caenorhabditis elegans. Genetics 96:649–664
Roberts PA (1976) The genetics of chromosome aberration. In: Ashburner M, Novitski E (eds) The genetics and biology of Drosophila, vol Ia. Academic Pres, New York, pp 68–184
Rose AM, Baillie DL (1979a) The effect of temperature and parental age on recombination and nondisjunction in Caenorhabditis elegans. Genetics 92:409–418
Rose AM, Baillie DL (1979b) A mutation in Caenorhabditis elegans that increases recombination frequency more than threefold. Nature 281:599–600
Rose AM, Baillie DL (1980) Genetic organization of the region around unc-15(I), a gene affecting paramyosin in Caenorhabditis elegans. Genetics 96:639–648
Rose AM, Baillie DL, Candido EPM, Beckenbach, Nelson D (1982) The linkage mapping of cloned restriction fragment length differences in Caenorhabditis elegans. Mol Gen Genet 188:286–291
Rosenbluth RE, Baillie DL (1981) The genetic analysis of a reciprocal translocation, eT1(III,V), in Caenorhabditis elegans. Genetics 99:415–428
Sandler I (1956) Studies in T(1;4) Bs in Drosophila melanogaster. M. Sc. thesis, University of Missouri
Author information
Authors and Affiliations
Additional information
Communicated by G.R. Smith
Rights and permissions
About this article
Cite this article
Rose, A.M., Baillie, D.L. & Curran, J. Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans . Mol Gen Genet 195, 52–56 (1984). https://doi.org/10.1007/BF00332723
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00332723