Summary
Quantitative investigations were made on the effect of convulsant doses of pentamethylenetetrazol (PMT) on the neurones of the supraoptic nucleus in rabbit. In contrast to results reported by other workers, the present investigation yielded statistical evidence for an increase in the number of “Gomori-positive” elements in the supraoptic nucleus following epileptic seizures induced by PMT. The factors that might be responsible for this phenomenon are discussed. It is pointed out that a satisfactory interpretation cannot be given on the basis of histological findings alone. The problem requires further investigation with other techniques, such as electron microscopy and biochemical methods.
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Dedicated to Professor Dr. Dr. h.c. H. Spatz on the occasion of his 80th birthday.
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Christ, J.F., Jarosch, E. Quantitative investigations on the effect of pentamethylenetetrazol on the supraoptic neurones in rabbit. Z. Zellforsch. 93, 404–413 (1969). https://doi.org/10.1007/BF00332665
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DOI: https://doi.org/10.1007/BF00332665