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The growth-promoting action of Iron upon Acanthamoeba

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Summary

The growth-promoting effect of iron salts upon Acanthamoeba sp. Neff. was analyzed and it was found that this action persists after ultrafiltration and thus does not depend upon phagocytosis of particulate material, as has been suggested. Neither is the ultrafiltrable growth-promoting factor in proteose peptone of particulate nature but should have a gel structure. The mitogenetic action of iron was different for amoebae cultivated in neopeptone and proteose peptone, respectively. In neopeptone mainly the duration of growth is prolonged, while in proteose peptone only the rate of growth is increased. The growth-promoting actions of iron and phytohemoagglutinin are compared and found to he different. The iron may interfere with the ultrastructure of the nuclear membrane.

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Authors and Affiliations

  1. Zoophysiological Institute, University of Lund, Sweden

    Ivar P. S. Agrell

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  1. Ivar P. S. Agrell
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Valuable technical assistance was given by Miss Brita Nilsson.

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Agrell, I.P.S. The growth-promoting action of Iron upon Acanthamoeba . Z. Zellforsch. 118, 142–146 (1971). https://doi.org/10.1007/BF00331772

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  • DOI: https://doi.org/10.1007/BF00331772

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