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The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function

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Summary

A DNA fragment called suc1 has been found to rescue cells mutated in the cell cycle control gene cdc2 of the fission yeast Schizosaccharomyces pombe. The suppressing activity of suc1 is observed when it is present on a multicopy number plasmid. The gene does not hybridise to cdc2 and maps elsewhere in the genome. Its effect is cdc2 allele specific suggesting that it interacts directly with the cdc2 gene function.

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References

  • Beach D, Durkacz B, Nurse P (1982) Functionally homologous cell cycle control genes in budding and fission yeast. Nature 300:706–709

    Google Scholar 

  • Beach D, Piper M, Nurse P (1982) Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet 187:326–329

    Google Scholar 

  • Durkacz B, Beach D, Hayles J, Nurse P (1985) The fission yeast cell cycle control gene cdc2: structure of the cdc2 region. Mol Gene Genet 201:543–545

    Google Scholar 

  • Gutz H, Heslot H, Leupold U, Loprieno N (1974) Schizosaccharomyces pombe. In: King RC (ed) Handbook of Genetics, vol 1, Plenum Press, New York, pp 295–346

    Google Scholar 

  • Hindley J, Phear G (1984) Sequence of the cell division gene cdc2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases. Gene 31:129–134

    Google Scholar 

  • Lorincz A, Reed S (1984) Primary structure homology between the product of yeast cell division control gene cdc28 and vertebrate oncogeneses. Nature 307:183–185

    Google Scholar 

  • Nurse P (1985) Cell cycle control genes in yeast. Trends Genet 1:51–55

    Google Scholar 

  • Nurse P, Bissett Y (1981) Cell cycle gene required in G1 for commitment to cell division and in G2 for control of mitosis in fission yeast. Nature 292:558–560

    Google Scholar 

  • Nurse P, Thuriaux P (1980) Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics 96:627–637

    Google Scholar 

  • Pringle J, Hartwell L (1981) The Saccharomyces cerevisiae cell cycle. In: Strathern J, Jones E, Broach J (eds) The Molecular Biology of the Yeast Saccharomyces. Cold Spring Harbor Laboratory, New York, pp 97–143

    Google Scholar 

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Communicated by C. Auerbach

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Hayles, J., Beach, D., Durkacz, B. et al. The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet 202, 291–293 (1986). https://doi.org/10.1007/BF00331653

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  • DOI: https://doi.org/10.1007/BF00331653

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