Summary
The w m Co duplication of Drosophila hydei (Dp (1; Y) 16B2-17B1) contains 13–16 bands in salivary gland chromosomes. The duplication resides preferentially in the X heterochromatin or on the Y chromosome. In some stocks frequent (up to 4×10-3) exchanges of the duplication occur between different Y chromosomes (T(X; Y) and free Y) or between the X and the Y chromosome. About 60% of the T(X; Y)-Y exchanges induce mutations in the Y chromosomal male fertility genes of the recipient Y chromosome. From the mutational spectrum generated by the T(X; Y)-Y transpositions and from the variable efficiency as acceptor of different X-Y translocations it can be concluded that the exchanges show a remarkable site specificity: distal positions in the long arm of the Y chromosome are occupied preferentially. More proximal positions in the long arm of insertions into the short arm of the Y chromosome are found only with a lower frequency. No transpositions to the autosomes have been recovered. Duplications are lost with highly differing frequencies. The losses are not linked with insertions of the w m Co element into a new position and are more frequent than transpositions. Therefore, we regard the w m Co element as a giant transposon.
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Communicated by G. Campos-Ortega
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Hackstein, J.H.P., Hennig, W. & Siegmund, I. Y chromosome-specific mutations induced by a giant transposon in Drosophila hydei . Mol Gen Genet 207, 455–465 (1987). https://doi.org/10.1007/BF00331615
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DOI: https://doi.org/10.1007/BF00331615