Skip to main content
Log in

The restriction of the recombination of mitochondrial DNA molecules in the zygotes of Saccharomyces cerevisiae

  • Published:
Molecular and General Genetics MGG Aims and scope Submit manuscript

Summary

Crosses were made between strains carrying a nuclear control factor (NC) and strains classified with respect to their omega allele (ω+ or ω-). The characteristic asymmetrical transmission was always observed (as was seen) in crosses not involving the ω factor. The analysis of functional recombinants in a cross involving an NC factor has indicated that the absence of the ω effect may be caused by a restriction in the zygote of the recombination of mitochondrial DNA molecules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bolotin, M., Coen, D., Deutsch, J., Dujon, B., Netter, P., Slonimski, P. P.: Le recombinaison des mitochondries chez Saccharomyces cerevisiae. Bull. Inst. Pasteur 69, 215–239 (1971)

    Google Scholar 

  • Callen, D.: The effect of mating type on the polarity of mitochondrial gene transmission in Saccharomyces cerevisiae. Molec. gen. Genet. 128, 321–329 (1974a)

    Google Scholar 

  • Callen, D. F.: Recombination and segregation of mitochondrial genes in Saccharomyces cerevisiae. Molec. gen. Genet. 134, 49–63 (1974b)

    Google Scholar 

  • Callen, D. F.: Segregation of mitochondrially inherited antibiotic resistance genes in zygote cell lineages of Saccharomyces cerevisiae. Molec. gen. Genet. 134, 65–76 (1974c)

    Google Scholar 

  • Coen, D., Deutsch, J., Netter, P., Petrochilo, E., Slonimski, P. P.: Mitochondrial genetics. I. Methodology and phenomenology. In: Control of organelle development, Soc. Exp. Biol. Symp., vol. 24 (ed. P. L. Muller), p. 449–496. New York: Academic Press 1970

    Google Scholar 

  • Deutsch, J., Dujon, B., Netter, P., Petrochilo, E., Slonimski, P. P., Bolotin-Fukuhara, M., Coen, D.: Mitochondrial genetics VI. The petite mutation in Saccharomyces cerevisiae: interrelations between the loss of the factor and the loss of the drug resistance mitochondrial genetic markers. Genetics 76, 195–219 (1974)

    Google Scholar 

  • Dujon, B., Kruszewska, A., Slonimski, P. P., Bolotin-Fukuhara, M., Coen, D., Deutsch, J., Netter, P., Weill, L.: Mitochondrial genetics X: Effects of UV irradiation on transmission and recombination of mitochondrial genes in Saccharomyces cerevisiae. Molec. gen. Genet. 137, 29–72 (1975)

    Google Scholar 

  • Dujon, B., Slonimski, P. P., Weill, L.: Mitochondrial genetics. IX. A model for recombination and segregation of mitochondrial genomes in Saccharomyces cerevisiae. Genetics 78, 415–437 (1974)

    Google Scholar 

  • Lukins, H., Tate, J. R., Saunders, G. W., Linnane, A. W.: The biogenesis of mitochondria, 26. Mitochondrial recombination: the segregation of parental and recombinant mitochondrial genotypes during vegetative division of yeast. Molec. gen. Genet. 120, 17–25 (1973)

    Google Scholar 

  • Perlman, P. S., Birky, C. W., Jr.: Mitochondrial genetics in Baker's yeast: a molecular mechanism for recombinational polarity and suppressiveness. Proc. nat. Acad. Sci. (Wash.) 71, 4612–4616 (1974)

    Google Scholar 

  • Rank, G. H., Bech-Hansen, N. T.: Somatic segregation, recombination, asymmetrical distribution and complementation tests of cytoplasmically-inherited antibiotic-resistance mitochondrial markers in S. cerevisiae. Genetics 72, 1–15 (1972)

    Google Scholar 

  • Saunders, G. W., Gingold, E. B., Trembath, M. K., Lukins, H. B., Linnane, A. W.: Mitochondrial genetics in yeasts: Segregation of a cytoplasmic determinant in crosses and its loss or retention in the petite. In: Autonomy and biogenesis of mitochondria and chloroplasts (Boardman, N. K., Linnane, A. W., and Smillie, R. D., eds.), p. 185–193. New York: North Holland Publishing Co. 1971

    Google Scholar 

  • Waxman, M. F.: On the nature of the control of the transmission and expression of mitochondrial antibiotic resistance factors in Saccharomyces cerevisiae Ph.D. thesis, City University of New York, New York (1974)

    Google Scholar 

  • Waxman, M. F., Eaton, N. R.: Nuclear factors and the control of suppressiveness in petite mutants of Saccharomyces cerevisiae. Molec. gen. Genet. 133, 37–45 (1974)

    Google Scholar 

  • Waxman, M. F., Eaton, N. R., Wilkie, D.: Effect of antibiotics on the transmission of mitochondrial factors in Saccharomyces cerevisiae. Molec. gen. Genet. 127, 277–284 (1973)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Communicated by Ch. Auerbach

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waxman, M.F. The restriction of the recombination of mitochondrial DNA molecules in the zygotes of Saccharomyces cerevisiae . Molec. gen. Genet. 141, 285–290 (1975). https://doi.org/10.1007/BF00331450

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00331450

Keywords

Navigation