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Adrenergic innervation of the umbilical vessels

Light- and fluorescence microscopic studies

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Summary

The intra- and extrafetal portions of the umbilical vessels in the guinea-pig and the umbilical cord of man, mouse and rabbit have been investigated by means of the Falck-Hillarp method for the fluorescence microscopical demonstration of catecholamines.

The umbilical cord was found to be devoid of nerves in all species investigated. Adrenergic nerves are present only in the immediate vicinity of the umbilicus.

The intrafetal portions of the umbilical artery and umbilical vein receive adrenergic nerves, the distribution pattern of which is different for each vessel. In the guinea-pig the ductus venosus is an intrahepatic branch of the vena umbilicalis. No adrenergically innervated sphincter has been detected in the initial segment of the ductus venosus. Regional variations in the pattern of innervation of the intrafetal portion of the umbilical vein are paralleled by regional differences in the construction pattern of the vessel's wall. Regional differences in the noradrenaline concentration (measured by fluorometry) which correspond to the fluorescence microscopical findings have been detected in umbilical vessels: low noradrenaline content of the umbilical cord, high concentrations in the intrafetal sections of the umbilical vessels. The noradrenaline concentration of the guinea-pig umbilical artery is three times that of the umbilical vein.

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Authors and Affiliations

  1. Institute of Anatomy, University of Hamburg, Deutschland

    Lutz Lachenmayer

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  1. Lutz Lachenmayer
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Supported by the Joachim Jungius-Gesellschaft der Wissenschaften, Hamburg.

For continuous advice and constructive criticism I am indebted to Prof. Dr. Dr. E. Horstmann.

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Lachenmayer, L. Adrenergic innervation of the umbilical vessels. Z. Zellforsch. 120, 120–136 (1971). https://doi.org/10.1007/BF00331246

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  • DOI: https://doi.org/10.1007/BF00331246

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