Abstract
Cultured embryonic cells from Rattus (Mastomys) natalensis were treated with the base analogues 5-bromodeoxyuridine and 2-aminopurine, the viruses herpes simplex virus and adenovirus type 12, and the carcinogens 7,12-dimethylbenz(a)anthracene and urethan. Treatment with these agents, except urethan, causes an increase in the incidence of chromosome aberrations. The induced aberrations are not randomly distributed among the chromosomes or within a chromosome. The X chromosome, especially its long arm, is more sensitive to these agents than is any other chromosomes in the complement. — A possible relationship among the high incidence of damage, the positive heteropycnosis, and the late replication in the X chromosome of R. natalensis is discussed.
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Huang, G.C. Induction of a high incidence of damage to the X chromosomes of Rattus (Mastomys) natalensis by base analogues, viruses, and carcinogens. Chromosoma 23, 162–179 (1967). https://doi.org/10.1007/BF00331111
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DOI: https://doi.org/10.1007/BF00331111