Skip to main content
SpringerLink
Log in

The effect of inversions on mitotic recombination in Drosophila melanogaster

  • Published:
Molecular and General Genetics MGG Aims and scope Submit manuscript

Summary

The effect of inversions on mitotic recombination outside the inversion was studied in inversion-heterozygotes. Seven euchromatic inversions of the X-chromosome, with breakpoints within the interval between two cell markers, were chosen. The size of the inverted region and the distance from the proximal breakpoint to the proximal cell marker varied. Mitotic recombination was X-ray induced in larvae and clones scored in the tergites of emerged adults. The frequency of recombinants between both cell markers and the frequency of recombinants proximal to the proximal cell marker was used to estimate the effect of interference in pairing caused by the inversions. Such an effect only occurs in small chromosome intervals. This indicates that homologous sequences are tightly paired in the interphase nuclei of somatic cells. This conclusion is derived from data based on X-ray induced mitotic recombination. The possibility of extending this conclusion to non-irradiated cells is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ashburner, M.: Gene activity dependent on chromosome synapsis in the polytene chromosome of Drosophila melanogaster. Nature (Lond.) 214, 1154–1160 (1967)

    Google Scholar 

  • Becker, H.J.: The influence of heterochromatin, inversion-heterozygosity and somatic pairing on X-ray induced mitotic recombination in Drosophila melanogaster. Molec. gen. Genet. 105, 203–218 (1969)

    Google Scholar 

  • Becker, H.J.: Mitotic recombination. In: The genetics and biology of Drosophila (Ashburner, M. and Novitsky, E. eds.), Vol. 1c. New York: Academic Press 1976

    Google Scholar 

  • Cooper, K.W.: The evidence for long range specific attractive forces during the somatic pairing of dipteran chromosomes. J. exp. Zool. 108, 327–336 (1948)

    Google Scholar 

  • Garcia-Bellido, A.: Some parameters of mitotic recombination in Drosophila melanogaster. Molec. gen. Genet. 115, 54–72 (1972)

    Google Scholar 

  • García-Bellido, A., Merriam, J.R.: Clonal parameters of tergite development in Drosophila. Develop. Biol. 26, 264–276 (1971)

    Google Scholar 

  • Gillies, C.B.: Syneptonemal complex and chromosome structure. Ann. Rev. Genet. 9, 91–109 (1975)

    Google Scholar 

  • Guerra, M., Postlethwait, J.H., Schneiderman, H.A.: The development of the imaginal abdomen of Drosophila melanogaster. Develop. Biol. 32, 361–372 (1973)

    Google Scholar 

  • Haendle, J.: X-ray induced mitotic recombination in Drosophila melanogaster. III. Dose dependence of the “pairing” component. Molec. gen. Genet. 128, 233–239 (1974)

    Google Scholar 

  • Halfer, C., Barigozzi, C.: Prophase synapsis in mitoses of Drosophila somatic cells. Genet. Iber. 24, 211–233 (1972)

    Google Scholar 

  • Kaufmann, B.P.: Somatic mitoses of Drosophila melanogaster. J. Morph. 56, 125–155 (1934)

    Google Scholar 

  • Lewis, E.B.: The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. Amer. Nat. 88, 225–239 (1954)

    Google Scholar 

  • Lindsley, D.L., Grell, E.H.: Genetic variations of Drosophila melanogaster. Carn. Inst. Wash. Publ. No. 627 (1968)

  • Merriam, J.R., Fyffe, W.E.: The kinetics of X-ray induced somatic crossing-over in Drosophila melanogaster and the effects of dose fractionation. Mutation Res. 14, 309–314 (1972)

    Google Scholar 

  • Merriam, J.R., García-Bellido, A.: A model for somatic pairing derived from somatic crossing over with third chromosome rearrangements in Drosophila melanogaster. Molec. gen. Genet. 115, 302–313 (1972)

    Google Scholar 

  • Merriam, J.R., Nöthiger, R., García-Bellido, A.: Are dicentric anaphase bridges formed by somatic recombination in X chromosome inversion heterozygotes of Drosophila melanogaster? Molec. gen. Genet. 115, 294–301 (1972)

    Google Scholar 

  • Ripoll, P.: Behavior of somatic cells homozygous for zygotic lethals in Drosophila melanogaster. Genetics 86, 357–376 (1977)

    Google Scholar 

  • Ripoll, P., Garcia-Bellido, A.: Mitotic recombination in the heterochromatin of the sex-chromosomes of Drosophila melanogaster. Genetics (in press) (1978)

  • Stern, C.: Somatic crossing over and segregation in Drosophila melanogaster. Genetics 21, 625–730 (1936)

    Google Scholar 

  • Stern, C.: Somatic recombination whithin the white locus of Drosophila melanogaster. Genetics 62, 573–581 (1969)

    Google Scholar 

  • Stone, W., Thomas, I.: Crossover and disjunctional properties of X chromosome inversions in Drosophila melanogaster. Genetics 17, 170–184 (1935)

    Google Scholar 

  • Sturtevant, A.H., Beadle, G.: The relations of inversions in the X chromosome of Drosophila melanogaster to crossing over and non-disjunction. Genetics 21, 554–604 (1936)

    Google Scholar 

  • Tokunaga, C.: Intragenic somatic recombination in the lozenge cistron of Drosophila. Molec. gen. Genet. 125, 1109–1118 (1973)

    Google Scholar 

  • Westergaard, M., Wettstein, D.V.: The syneptonemal complex. Ann. Rev. Genet. 6, 71–110 (1972)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro de Bíología Molecular, C.S.I.C., Facultad de Ciencias, C-X, Universidad Autónoma de Madrid, Madrid-34, Spain

    A. García-Bellido & F. Wandosell

Authors
  1. A. García-Bellido
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Wandosell
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Communicated by K. Illmensee

Rights and permissions

Reprints and permissions

About this article

Cite this article

García-Bellido, A., Wandosell, F. The effect of inversions on mitotic recombination in Drosophila melanogaster . Molec. gen. Genet. 161, 317–321 (1978). https://doi.org/10.1007/BF00331007

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00331007

Keywords

Search

Navigation