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Bifunctionality and polarized infidelity at the hisB locus of Aspergillus nidulans

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Summary

The histidine (hisB) locus of Aspergillus nidulans is unusual in two ways. Firstly, it is bifunctional; besides coding for imidazole glycerol phosphate (IGP) dehydrase, it is required for the production of ascospores (fertility). It appears, therefore, to be partly homologous to the hisB locus of Salmonella typhimurium, which codes for IGP dehydrase and histidinol phosphate phosphatase. Secondly, during meiosis it is often inaccurately transmitted to the progeny (infidelity). This phenomenon may be akin to the aberrant recombination events which cause Bar reversion in Drosophila, “selfing” in Salmonella and Neurospora, and gene fusions of the haemoglobin lepore type. A molecular model is proposed to account for the results.

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Author notes

  1. A. M. Millington Ward, E. A. Klasen & M. Bresser

    Present address: Sylvius Laboratoria, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands

Authors and Affiliations

  1. Genetisch Laboratorium, Rijksuniversiteit, Kaiserstraat 63, Leiden, The Netherlands

    A. M. Millington Ward, J. A. M. Reuser, J. Y. Scheele, E. J. van Lohuizen, I. R. M. C. van Gorkum van Diepen, E. A. Klasen & M. Bresser

Authors
  1. A. M. Millington Ward
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  2. J. A. M. Reuser
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  3. J. Y. Scheele
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  4. E. J. van Lohuizen
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  5. I. R. M. C. van Gorkum van Diepen
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  6. E. A. Klasen
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  7. M. Bresser
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Communicated by W. Gajewski

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Ward, A.M.M., Reuser, J.A.M., Scheele, J.Y. et al. Bifunctionality and polarized infidelity at the hisB locus of Aspergillus nidulans . Molec Gen Genet 193, 332–339 (1984). https://doi.org/10.1007/BF00330690

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  • DOI: https://doi.org/10.1007/BF00330690

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