Abstract
The sequence of DNA replication was studied within the inactive X chromosome in human lymphocytes, by means of the FPG method. Several variants of the replication sequence were found. The number of variants in the cells of a single donor exceeded 2 in each of the 4 normal individuals studied. The phenomenon is discussed with respect to the regulation of DNA synthesis and to the cell differentiation process.
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Schmidt, M., Stolzmann, W.M. & Baranovskaya, L.I. Replication variants of the human inactive X chromosome. Chromosoma 85, 405–412 (1982). https://doi.org/10.1007/BF00330363
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DOI: https://doi.org/10.1007/BF00330363