Summary
The characteristic findings on computed tomography (CT) in multiple sclerosis (MS) are discussed. In a series of 49 cases plain CT was normal in 21 (43%), cerebral atrophy alone was present in 17 (35%) and plaques were visible in 11 (23%). These were most often adjacent to the lateral ventricles (14 plaques) and in the parietal white matter (10 plaques).
CT was performed after the intravenous administration of iodide in 16 of these cases. Three of the low attenuation and three additional isodense lesions enhanced. Two patients with low attenuation plaques were scanned with xenon enhancement; the plaques absorbed less xenon than the corresponding contralateral brain substance and additional, previously isodense plaques were revealed. In one case the white matter absorbed much less xenon than normal and its uptake relative to grey matter was reduced.
Similar content being viewed by others
References
Broman, T.: Blood-brain barrier damage in multiple sclerosis supra-vital test observations. Acta neurol. (Scand.) 40, Supplement 10, 21–24 (1964)
Brownell, B., Hughes, J.T.: The distribution of plaques in the cerebrum in multiple sclerosis. J. Neurol. Neurosurg. Psychiat. 25, 315–320 (1962)
Cole, M., Ross, J.R.: Plaque of multiple sclerosis seen on computerized axial tomogram. Neurology (Minneapolis) 27, 890–891 (1977)
Cullen, S.C., Gross, E.G.: Anesthetic properties of Xenon and Krypton. Science 113, 580–582 (1951)
Gyldensted, C.: Computer tomography of the cerebrum in multiple sclerosis. Neuroradiology 12, 33–42 (1976)
Huckman, M.S., Fox, J.H., Ramsey, R.G.: Degenerative disease of the brain. Computed cranial tomography. Semin. Roentgenol. 12, 61–73 (1977)
Jacobs, L., Kinkel, W.R.: Computerized axial tomography in multiple sclerosis. Neurology (Minneapolis) 26, 390–391 (1976)
Lumsden, C.E.: The neuropathology of multiple sclerosis. Handbook of Clinical Neurology 9, 217–309. (Ed. Vinken, P.J., Bruyn, G.W.). Amsterdam: North Holland 1970
McIlwain, H., Buchclard, H.S.: Biochemistry and the central nervous system, pp. 371–385. London: Churchill Livingstone 1971
Winkler, S.S., Sackett, J.F., Holden, J.E., Fleming, D.C., Alexander, S.C., Madsen, M., Kimmel, R.I.: Xenon inhalation as an adjunct to computerized tomography of the brain. Preliminary study. Invest. Radiol. 12, 15–18 (1977)
Wüthrich, R., Gigli, H., Wiggli, U., Muller, H.R., Elke, M., Hunig R.: C.T. scanning in demyelinating disease in cranial computerised tomography, pp. 239–243 (Ed. Lanksch and Kazner). Berlin, Heidelberg, New York: Springer 1976
Zilkha, E., Ladurner, G., Iliff Linnette D., du Boulay, G.H., Marshall, J.: Computer subtraction in regional cerebral bloodvolume measurements using the EMI scanner (ab)
Author information
Authors and Affiliations
Additional information
EMI Research Fellow
Rights and permissions
About this article
Cite this article
Radue, E.W., Kendall, B.E. Iodide and xenon enhancement of computed tomography (CT) in multiple sclerosis (MS). Neuroradiology 15, 153–158 (1978). https://doi.org/10.1007/BF00329059
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00329059