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Oncogenes and linkage groups: Conservation during mammalian chromosome evolution

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Abstract

Proto-oncogenes, which represent the cellular progenitors of the transforming genes harbored by acute transforming oncogenic retroviruses, have been highly conserved during vertebrate evolution. In this report, we have assigned experimentally a subset of proto-oncogenes (SRC, ABL, FES, and FMS — all related to the SRC family) to Chinese hamster chromosomes by Southern filter hybridization analyses of DNAs isolated from both somatic cell hybrids and flow-sorted hamster chromosomes. These results demonstrate that several autosomal linkage groups containing proto-oncogenes originated prior to the radiation and speciation of mammals and have remained remarkably stable for nearly 80 million years.

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Authors and Affiliations

  1. Los Alamos National Laboratory, Genetics and Experimental Pathology Groups, Life Sciences Division, The University of California, 87545, Los Alamos, NM, USA

    Raymond L. Stallings, A. Christine Munk, Jonathan L. Longmire, James H. Jett, Mark E. Wilder & Brian D. Crawford

  2. The University of Texas System Cancer Center, Department of Genetics, M.D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Michael J. Siciliano

  3. Science Park Research Division, The University of Texas System Cancer Center, 78957, Smithville, TX, USA

    Gerald M. Adair

Authors
  1. Raymond L. Stallings
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  2. A. Christine Munk
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  6. Michael J. Siciliano
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  7. Gerald M. Adair
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  8. Brian D. Crawford
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Stallings, R.L., Munk, A.C., Longmire, J.L. et al. Oncogenes and linkage groups: Conservation during mammalian chromosome evolution. Chromosoma 92, 156–163 (1985). https://doi.org/10.1007/BF00328468

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  • DOI: https://doi.org/10.1007/BF00328468

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