Summary
Using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) five different β-chain patterns of denaturated human C4 were observed: C4βH, βH>L, βH=L, β H<L, and β L. In 32 families with 174 offspring the segregation of C4 β-chain types followed that of the other major histocompatibility complex (MHC) markers. It is concluded that the C4 β-chain patterns represent a genetically determined polymorphism, coded within the known C4A and B gene region.
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Mauff, G., Steuer, M., Weck, M. et al. The C4 β-chain: Evidence for a genetically determined polymorphism. Hum Genet 64, 186–188 (1983). https://doi.org/10.1007/BF00327123
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DOI: https://doi.org/10.1007/BF00327123