Human Genetics

, Volume 64, Issue 2, pp 116–121 | Cite as

Clinical heterogeneity in the tricho-dento-osseous syndrome

  • F. Quattromani
  • S. D. Shapiro
  • R. S. Young
  • R. J. Jorgenson
  • J. W. Parker
  • R. Blumhardt
  • R. R. Reece
Original Investigations

Summary

The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis.

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References

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • F. Quattromani
    • 1
  • S. D. Shapiro
    • 2
  • R. S. Young
    • 2
  • R. J. Jorgenson
    • 2
  • J. W. Parker
    • 3
  • R. Blumhardt
    • 4
  • R. R. Reece
    • 5
  1. 1.Department of Radiology2nd General HospitalLandstuhlFederal Republic of Germany
  2. 2.Department of Periodontics and Genetics School of DentistryUniversity of Texas Health Science CenterSan AntonioUSA
  3. 3.Department of PediatricsBrooke Army Medical CenterFort Sam HoustonUSA
  4. 4.the Department of RadiologyBrooke Army Medical CenterFort Sam HoustonUSA
  5. 5.Department of RadiologyWilliam Beaumont Army Medical CenterEl PasoUSA

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