Clinical heterogeneity in the tricho-dento-osseous syndrome
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The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis.
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- Cole HN, Dirver JR, Girffen HK, Norris CB, Stroud G (1941) Ectodermal and mesodermal dysplasia with osseous involvement. Arch Dermatol 44:773–788Google Scholar
- Darwin C (1863) Animals and plants under domestication, vol 2. Orange Judd and Company, New York, p 393Google Scholar
- Gulmen S, Pullon PA, O'Brien LW (1976) Tricho-dento-osseous syndrome J Endod 2:117–120bGoogle Scholar
- Hansman CF (1966) Growth of interorbital distance and skull thickness as observed in roentgenographic measurements. Radiology 86: 87–96Google Scholar
- Jorgenson RJ, Warson RW (1973) Dental abnormalities in the tricho-dento-osseous syndrome. Oral Surg 36:693–700Google Scholar
- Lichtenstein J, Warson R, Jorgenson R, Dorst JP, McKusick VA (1972) The tricho-dento-osseous (TDO) syndrome. Am J Hum Genet 24: 569–582Google Scholar
- Melnick M, Shields ED, El-Kafrawy AH (1977) Tricho-dento-osseous syndrome: a scanning electron microscopic analysis. Clin Genet 12:17–27Google Scholar
- Porter PS, Lobitz WC (1970) Human hair: a genetic marker. Br J Dermatol 83:225–239Google Scholar
- Robinson GC, Miller J, Worth HM (1966) Hereditary enamel hypoplasia; its association with characteristic hair structure. Pediatrics 37: 498–502Google Scholar
- Sedgwick (1868) Brit and Foreign Medico-chirurg, Review, p 453Google Scholar
- Thadani KI (1921) A toothless type of man. J Hered 12:87–88Google Scholar