Summary
A perceived disadvantage of fine needle aspiration biopsy is that aspiration biopsy cytology cannot be correlated with tissue grading systems based on tissue patterns of prostate carcinoma. We feel that it is possible to predict tissue patterns of prostate carcinoma and to estimate Gleason's scores in aspiration biopsy specimens. Cytologically, prostate carcinomas may be reduced to those with glands, cribriform patterns, or undifferentiated solid or discohesive structures. Tumor grading based on patterns of prostate carcinoma may have significant impact on judging patient prognosis and on determining optimum patient therapy by allowing the urologist to apply the vast bank of existing data based on tissue studies to the interpretation of material obtained by fine needle aspiration biopsy of the prostate gland.
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References
Broders AC (1926) Carcinoma: grading and practical application. Arch Pathol Lab Med 68:376–381
Gleason DF (1966) Classification of prostatic carcinomas. Cancer Chemother Rep 50:125–128
Gaeta JF, Asirwatham JE, Miller G, Murphy GP (1980) Histological grading of primary prostatic cancer: a new approach to an old problem. J Urol 123:689–693
Horada M, Mostofi FK, Carle DK, Trump BF (1977) Preliminary studies of histologic prognosis in cancer of the prostate. Cancer Treat Rep 61:223–225
Utz DC, Farrow GM (1969) Pathologic differentiation and prognosis of prostatic carcinoma. J Am Med Assoc 209:1701–1703
Brown PN, Ayala AG, von Eschenbach AC, Hussey DH, Johnson DE (1982) Histologic grading study of prostate adenocarcinoma: the development of a new system and comparison with other methods. A preliminary study. Cancer 49:525–532
Bauer WC, McGavran MH, Carlin MR (1960) Unsuspected carcinoma of the prostate in suprapubic prostatectomy specimens: a clinicopathological study of 55 consecutive cases. Cancer 13:370–378
Shelly HS, Auerbach SH, Classen KL, Marks CH, Wideranders RE (1958) Carcinoma of the prostate. Arch Surg 77:751–756
Evans N, Barnes RW, Brown AF (1942) Carcinoma of the prostate. Correlation between histologic observations and the clinical course. Arch Pathol 34:473–483
Bocking A, Kiehn J, Heinzel-Wach M (1982) Combined histologic grading of prostatic carcinoma. Cancer 50:288–294
Diamond DA, Berry SJ, Jewett HJ, Eggleston JC, Coffey DS (1982) A new method to assess metastatic potential of human prostate cancer: relative nuclear roundness. J Urol 128:729–734
Tannenbaum M, Tannenbaum S, Desanctis PR, Olsson CA (1982) Prognostic significance of nucleolar surface area in prostate cancer. Urology 19:546–551
Benson MC, Walsh PC (1986) The application of flow cytometry to the assessment of tumor cell heterogeneity and the grading of human prostatic cancer: preliminary results. J Urol 135:1194–1198
Mostofi FK (1976) Problems of grading carcinoma of the prostate. Sem Oncol 3:161–169
Epstein NA, Fatti LP (1976) Prostatic carcinoma. Some morphological features affecting prognosis. Cancer 37:2455–2465
Dohm G (1977) Classification and grading of prostate carcinoma. Rec Results in Canc Res 60:14–26
Gleason DF (1977) Histologic grading and clinical staging of prostatic carcinoma. Chap 9. In: Tannenbaum M (ed) Urology Pathology; the prostate. Lea & Febiger, Philadelphia
Gleason DF, Mellinger GT (1974) The veterans administration cooperative urological research group: prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 111:58–64
Murphy GP, Whitmore WF (1979) A report on the workshops on the current status of the histologic grading of prostate cancer. Cancer 44:1490–1494
Esposti PL (1974) Aspiration biopsy cytology in the diagnosis of management of prostatic carcinoma. Stahl and Accidens Tryck, Stockholm
Alfthan O, Klintrup HE, Koivuniemi A, Taskinen E (1970) Cytological aspiration biopsy and Vim-Silverman biopsy in the diagnosis of prostatic carcinoma. Chir Gynaec Fenn 59:226–229
Ekman H, Kersti H, Persson S (1967) Cytological vs histological examination of needle biopsy specimens in the diagnosis of prostatic cancer. Br J Urol 39:544–548
Epstein NA (1976) Prostatic biopsy. A morphologic correlation of aspiration cytology with needle biopsy histology. Cancer 38:2078–2087
Kelsey DM, Kohler FP, Mackinney CC, Kline TS (1976) Outpatient needle aspiration biopsy of the prostate. J Urol 116:327–328
Kline TS, Kelsey DM, Kohler PF (1977) Prostatic carcinoma and needle aspiration biopsy. Am J Clin Pathol 67:131–133
Chodak GW, Bibbo M, Straus FH, Wied GL (1984) Transrectal aspiration biopsy versus transperineal core biopsy for the diagnosis of carcinoma of the prostate. J Urol 132:480–482
Carter HB, Riehle RA, Koizumi JH, Amberson J, Vaughn ED (1986) Fine needle aspiration of the abnormal prostate: a cytohistological correlation. J Urol 135:294–298
Ljung B-M, Cherrie R, Kaufman JJ (1986) Fine needle aspiration biopsy of the prostate gland: a study of 103 cases with histological followup. J Urol 135:955–958
Whelan JP, Chin JL, Shapre JR, Davis IR (1986) Transrectal needle aspiration versus transperineal needle biopsy in diagnosis of carcinoma of prostate. Urol 27:410–414
Kline TS (1984) Guides to clinical aspiration biopsy: prostate. Igaku-Shoin, New York
Maksem JA, Johenning PW, Suarez M (1986) Is cytology capable of adequately grading prostate carcinoma? A matched series of 50 cases. Presented at the AUA Northcentral Section Meeting
Zattoni F, Pagano F, Rebuffi A, Costantin G (1983) Transrectal thin-needle aspiration biopsy of the prostate: four years' experience. Urol 22:69–72
Kramer SA, Tatum AC, Walker A, Hinshaw W, Cox E, Paulson DF (1981) Histologic grading as a predictor of response to chemotherapy in patients with prostatic carcinoma. Urology 18:377–379
Paulson DF, Piserchia PV, Gardner W (1980) Predictors of lymphatic spread in prostatic adenocarcinoma: uro-oncology research group study. J Urol 123:697–699
Kramer SA, Spahr J, Brendler CB, Glenn JF, Paulson DF (1980) Experience with Gleason's histopathologic grading in prostatic cancer. J Urol 124:223–225
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Maksem, J.A., Resnick, M.I. & Johenning, P.W. Can a cytological grading system be predictive of gleason's scores in aspiration biopsy cytology specimens of prostate carcinoma. World J Urol 5, 99–102 (1987). https://doi.org/10.1007/BF00327066
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DOI: https://doi.org/10.1007/BF00327066