Skip to main content

Advertisement

SpringerLink
Log in

Tumor markers for prostate cancer: update

  • Published:
World Journal of Urology Aims and scope Submit manuscript

Summary

The clinical applications of prostatic acid phosphatase (PAP) and prostate-specific antigen (PA) have been reviewed. Both PAP and PA cannot be used for screening or detection of intracapsular prostate cancer but simultaneous determination appears to be additive. Also, both are useful for monitoring disease recurrence and treatment response. The identification of either one or both antigens by immunoperoxidase techniques is useful for determining the prostatic origin of metastasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dmochowski A, Assenhajm D (1935) Über Harn- und Blut-phosphatase. Naturwissenschaften 23:501–505

    Google Scholar 

  2. Kutscher W, Wolbergs H (1935) Prostataphosphatase. Z Physiol Chem 236:237–240

    Google Scholar 

  3. Gutman EB, Sproul EE, Gutman AB (1936) Significance of increased phosphatase activity of bone at the site of osteoblastic metastasis secondary to carcinoma of the prostate gland. Am J Cancer 28:485–488

    Google Scholar 

  4. Sodeman TM, Batsakis (1977) Acid phosphatase. In: Tannenbaum M (ed) Urologic pathology. The prostate. Lea & Febiger, Philadelphia, pp 125–139

    Google Scholar 

  5. Shulman SL, Mamrod M, Gonder WA (1964) The detection of prostatic acid phosphatase by antibody reactions in gel diffusion. J Immunol 93:474–480

    Google Scholar 

  6. Romas NA (1983) Prostatic acid phosphatase: current concepts. Semin in Urolo 1:177–185

    Google Scholar 

  7. Romas NA, Hsu KC, Tomashefsky P, Tannenbaum M (1978) Counterimmunoelectrophoresis for detection of human prostatic acid phosphatase. Urology 12:79–83

    Google Scholar 

  8. Galen RE, Gambino SR (1975) The predictive value and efficiency of medical diagnosis. John Wiley and Sons, New York

    Google Scholar 

  9. Bruce AW, Mahan DE, Belville WD (1980) The role of the radioimmunoassay for prostatic acid phosphatase in prostate carcinoma. In: Droller MJ (ed) Controversies in urologic oncology. The Urologic Clinics of North America, Philadelphia, pp 645–652

    Google Scholar 

  10. Romas NA, Shaw LM, Hsu KC, Yin P, Pitts M, Tannenbaum M (1982) Clinical comparison of immunological assays for determining prostatic acid phosphatase. In: Shaw LM, Romas NA, Cohen H (eds) Prostatic acid phosphatase measurement: its role in detection and management of prostatic cancer. New York Academy of Sciences, New York, pp 104–109

    Google Scholar 

  11. Griffiths JC (1980) Prostate-specific acid phosphatase: reevaluation of radioimmunoassay in diagnosing prostatic disease. Clin Chem 26:433–436

    Google Scholar 

  12. Fair WR, Heston WDW, Kadman D, Crane DB, Catalona WJ, Ladenson JH, McDonald JM, Noll BW, Harvey G (1982) Prostatic cancer, acid phosphatase, creatine Kinase-BB and race: a prospective study. J Urol 128:735–738

    Google Scholar 

  13. Carson JL, Eisenberg JM, Shaw LM, Kindel HL, Soper KA (1985) Diagnostic accuracy of four assays of prostatic acid phosphatase. JAMA 253:665–669

    Google Scholar 

  14. Wang MC, Valanzuela LA, Murphy GP, Chu TM (1979) Purification of a human prostate specific antigen. Invest Urol 17:159–163

    Google Scholar 

  15. Chu TM, Murphy GP (1986) What's new in tumor markers for prostate cancer. Urology 27:487–491

    Google Scholar 

  16. Kuriyama M, Wang MC, Pasidero LD, Killian CS, Shimano T, Valanzuela L, Nishiura T, Murphy GP, Chu TM (1980) Quantitation of prostate specific antigen in serum by a sensitive enzyme immunoassay. Cancer Res 40:4658–4662

    Google Scholar 

  17. Kuriyama M, Wang MC, Lee CI, Papsidero LD, Killian CS (1981) Use of human prostate-specific antigen in monitoring prostate cancer. Cancer Res 41:3874–3876

    Google Scholar 

  18. Killian CS, Yang N, Emrich LJ, Vargas FP, Kuriyama M, Wang MC, Slack NH, Papsidero LD, Murphy GP, Chu TM (1985) Prognostic importance of prostate-specific antigen for monitoring patients with localized prostate cancer. Cancer Res 45:886–891

    Google Scholar 

  19. Kuriyama M, Loor R, Wang MC, Lee C, Killian CS, Papsidero LD, Inaji H, Nishiura T, Slack NH, Murphy GP, Chu TM (1982) Prostatic acid phosphatase and prostate-specific antigen in prostate cancer. Int Adv Surg Oncol 5:29–49

    Google Scholar 

  20. Killian CS, Emrich LJ, Vargas FP, Yang N, Wang MC, Priole RL, Murphy GP, Chu TM (1986) Relative reliability of five serially measured markers for progression in prostate cancer. J Natl Cancer Inst 76:179–185

    Google Scholar 

  21. Raynor RH, Hazra TA, Moncure CW, Monhanakumar T (1984) Characterization of a monoclonal antibody, KR-P8, that detects a new prostate-specific marker. J Natl Cancer Inst 73:617–623

    Google Scholar 

  22. Goldenberg DM, Deland FH, Bennett SJ, Primus FJ, Nelson O, Flanigan RC, McRoberts W, Bruce AW, Mahan DE (1983) Radioimmunodetection of prostatic cancer. JAMA 250:630–635

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, St. Luke's-Roosevelt Hospital Center, and Columbia University, College of Physicians and Surgeons, 10019, New York, NY, USA

    N. A. Romas

Authors
  1. N. A. Romas
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Romas, N.A. Tumor markers for prostate cancer: update. World J Urol 5, 85–88 (1987). https://doi.org/10.1007/BF00327062

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00327062

Keywords

Search

Navigation