Summary
The pancreatic islets of the Axolotl (Siredon mexicanum) contain three types of cells with specific granulation: 1. A-cells are densly packed with ovoid electrondense α-granules, 2. B-cells with β-granules, which contain very often crystalline inclusions. 3. D-cells show structural similarities to the A-cells, but are distinguished according to the smaller size, lesser electrondensity, and distribution of their granules as a cell type of its own. In all three cell types lysosomal bodies and microtubules are seen. The periodic structure of the crystals in β-granules is described. Their possible relationship to sulfated-insulin and zinc-insulin is discussed.
Zusammenfassung
Das Inselorgan des Axolotl (Siredon mexicanum) enthält drei Zelltypen mit verschiedener spezifischer Granulation: 1. A-Zellen mit elektronendichten, dichtgepackten, kugeligen α-Granula, 2. B-Zellen mit β-Granula, die meist kristallinen Inhalt haben, 3. D-Zellen, die ähnliche Granula wie die A-Zellen aufweisen, doch durch ihre geringere Größe, Elektronendichte und Verteilung als eigener Zelltyp abgegrenzt werden können. Außerdem werden lysosomenartige Gebilde und Microtubuli beobachtet. Die periodische Struktur der Kristalle in den β-Granula wird beschrieben. Die Kristallform des Insulinsulfats und Zink-Insulins wird im Zusammenhang mit dem polymorphen Bild der β-Granula diskutiert.
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Grossner, D. Über das Inselorgan des Axolotl (Siredon mexicanum). Z. Zellforsch. 82, 82–91 (1967). https://doi.org/10.1007/BF00326102
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DOI: https://doi.org/10.1007/BF00326102