Summary
An electron microscopical study was made of the structure of the capillaries and of the surrounding cell formations in the chick telencephalon, during embryonic development and postnatal growth.
The capillary endothelium is present in the embryonic stage first studied (i. e. the 8-day old embryo). The basement membrane differentiates about the nineteenth day of embryonic development, and it is preceded by the appearance of the pericytes which are finally included in its structure.
The extracellular space in the vicinity of the capillaries, made of large gaps during the embryonic development, is confined from hatching time to intervals 150–200 Å diameter. The astrocytes and their processes (vascular feet) reach their complete development, and entirely surround the capillaries, on about the twentieth day of the postnatal growth.
Our observations reveal the close connection between the development of the pericapillary glial structures and the appearance of some mechanisms of the blood-brain barrier system in the chick.
Resumé
Une étude en microscopie électronique de la structure des capillaires et des formations cellulaires qui les entourent a été faite au niveau du télencéphale, chez le Poulet, au cours du développement embryonnaire et de la croissance postnatale.
L'endothélium capillaire est présent au premier stade embryonnaire étudié (embryon agé de 8 jours). La membrane basale se différencie vers le dix-neuvième jour du développement embryonnaire, et elle est précédée de l'apparition des péricytes qui restent inclus définitivement dans sa structure.
L'espace extracellulaire dans l'environnement des capillaires, constitué par de larges lacunes au cours du développement embryonnaire, se réduit dès l'éclosion à des intervalles de 150–200 Å de diamètre. Les astrocytes et leurs prolongements (pieds vasculaires) atteignent leur complet développement, et entourent totalement le capillaire, vers le vingtième jour de la croissance postnatale.
Nos observations mettent en évidence la relation étroite existant entre le développement des structures gliales péricapillaires et l'apparition de certains mécanismes du système de la barrière hémo-encéphalique chez le Poulet.
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Les auteurs remercient Madame R. Hatier de son excellente collaboration technique.
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Delorme, P., Grignon, G. & Gayet, J. Ultrastructure des capillaires dans le télencéphale du poulet au cours de l'embryogenèse et de la croissance postnatale. Z. Zellforsch. 87, 592–602 (1968). https://doi.org/10.1007/BF00325588
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DOI: https://doi.org/10.1007/BF00325588