Fresenius' Journal of Analytical Chemistry

, Volume 352, Issue 1–2, pp 92–96 | Cite as

The biological importance of nickel in the food chain

  • M. Anke
  • L. Angelow
  • M. Glei
  • M. Müller
  • H. Illing
Global Needs For RM


The ultra trace element nickel (Ni) is both essential and toxic for animals and humans. A Ni-poor nutrition of <0.1 mg/kg dry matter led to Ni deficiency symptoms. Ni is a component of the urease and it is also essential for several species of bacteria which occur in the rumen of ruminants. Ni deficiency symptoms, however, have not yet been found in animals and humans since the Ni offer exceeds the Ni requirement. On the other hand, an external Ni exposure to nickel alloys induces Ni dermatitis in 8 to 14% of nickel-sensitive women and in >1% of men after the filling of the Ni depot in the body. Experiments with 4 animal species showed that Ni exposure leads to disturbances in the Mg and above all in the Zn metabolism. Ni excess induces Zn deficiency symptoms which are similar to parakeratosis in pigs. They correspond to the symptoms of nickel allergy in humans. Therefore, the Ni intake of humans, which leads to the gradual filling of the Ni pool in the body and which can then induce nickel dermatitis in Ni-sensitive women and men, is of particular importance. The Ni requirement of adults does not exceed 25 to 35 μg/day. The Ni balance of men and women was positive (+20%) and shows the Ni incorporation even in the case of a Ni consumption which exceeds by far the requirement.


Nickel Alloy Ultra Trace Gradual Filling Element Nickel Nickel Allergy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Anke M (1961) Z. f. Acker- und Pflanzenbau 112:113–140Google Scholar
  2. 2.
    Anke M (1980) In: Anke M, Schneider H-J, Brückner Chr (eds) 3. Spurenelementsymposium. Nickel. Kongreß- und Werbedruck Oberlungwitz, pp 375–376Google Scholar
  3. 3.
    Anke M (1985) In: Gladtke E, Heimann PG, Lombeck I, Eckert I (eds) Spurenelemente: Stoffwechsel, Ernährung, Imbalance, Ultra-Trace-Elemente. Thieme, Stuttgart New York, pp 106–125Google Scholar
  4. 4.
    Anke M, Groppel B, Kronemann H, Grün M (1984) In: Sunderman FW Jr (ed) Nickel in the human environment. Oxford University Press, Oxford, pp 339–365Google Scholar
  5. 5.
    Anke M, Groppel B, Scholz E, Bauch K-H (1992) Mengen-und Spurenelemente 12:450–461Google Scholar
  6. 6.
    Anke M, Grün M, Groppel B, Kronemann H (1983) In: Sarkar B (ed) Biological aspects of metals and metal-related disease. Raven Press, New York, pp 89–105Google Scholar
  7. 7.
    Anke M, Lösch E, Angelow L, Drusch St, Müller M (1993) Mengen- und Spurenelemente 13:415–429Google Scholar
  8. 8.
    Anke M, Lösch E, Angelow L, Glei M, Arnhold W, Müller M, Illing H (1993) Mengen- und Spurenelemente 13:365–381Google Scholar
  9. 9.
    Anke M, Lösch E, Angelow L, Krämer K (1993) Mengen- und Spurenelemente 13:400–414Google Scholar
  10. 10.
    Anke M, Lösch E, Hübschmann J, Krämer K (1993) Mengen- und Spurenelemente 13:382–399Google Scholar
  11. 11.
    Anke M, Lösch E, Müller M, Groppel B, Kräuter U (1991) In: Anonym (ed) Umweltaspekte der Tierproduktion, vol 103. VDLUFA-Kongreß Ulm, pp 737–742Google Scholar
  12. 12.
    Anke M, Lösch E, Müller M, Krämer K, Glei M, Bugdol K (1992) In: International Potash Institute (ed) Potassium in ecosystems biogeochemical fluxes of cations in agro- and forest-systems. Brinkmann, Muhlhouse, pp 187–204Google Scholar
  13. 13.
    Anke M, Risch M (1979) Haaranalyse und Spurenelementstatus. Fischer, StuttgartGoogle Scholar
  14. 14.
    Brooks RR (1980) In: Nriagu JO (ed) Nickel in the environment. Wiley, New York, pp 407–430Google Scholar
  15. 15.
    Duke JM (1980) In: Nriagu JO (ed) Nickel in the environment. Wiley, New York, pp 27–50Google Scholar
  16. 16.
    Durum WH, Haffty J (1963) Geochim Cosmochim 27:1–11Google Scholar
  17. 17.
    Falbe J, Regitz M (1990) Römpp Chemie Lexikon. Thieme, StuttgartGoogle Scholar
  18. 18.
    McCabe LJ (1974) Proc Sixteenth Water Quality Conference. Trace metals in water supplies: Occurrence, significance and control. University of Illinois, Urbana, pp 1–10Google Scholar
  19. 19.
    Müller M (1993) Cadmiumaufnahme und Cadmiumausscheidung Erwachsener nach der Duplikat- und Marktkorbmethode. Dissertation, Friedrich-Schiller-Universität JenaGoogle Scholar
  20. 20.
    Nielsen FH (1987) In: Mertz W (ed) Trace elements in human and animal nutrition, 5th edn, vol 1. Academic Press, London, pp 245–273Google Scholar
  21. 21.
    Nielsen GD, Flyvholm M (1984) In: Sunderman FW Jr (ed) Nickel in the human environment. Oxford University Press, Oxford, pp 333–338Google Scholar
  22. 22.
    Nriagu JO (1980) In: Nriagu JO (ed) Nickel in the environment. Wiley, New York, pp 1–26Google Scholar
  23. 23.
    Oelschläger W (1955) Fresenius Z. Anal Chem 146:339–350Google Scholar
  24. 24.
    Rencz AN, Shilts WW (1980) In: Nriagu JO (ed) Nickel in the environment. Wiley, New York, pp 151–188Google Scholar
  25. 25.
    Richter RO, Theis TL (1979) In: Nriagu JO (ed) Biogeochemistry of nickel. McGraw-Hill, New YorkGoogle Scholar
  26. 26.
    Sunderman FW Jr (1984) Nickel in the human environment. Oxford University Press, OxfordGoogle Scholar
  27. 27.
    Sunderman FW Jr, Oskarsson A (1991) In: Merian E (ed) Metals and their compounds in the environment. VCH, Weinheim, pp 1101–1126Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Anke
    • 1
  • L. Angelow
    • 1
  • M. Glei
    • 1
  • M. Müller
    • 1
  • H. Illing
    • 1
  1. 1.Institute of Nutrition and EnvironmentFriedrich Schiller University JenaJenaGermany

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