Summary
The possible interrelation between infused bone marrow CFU-GM and peripheral granulocyte recovery was studied in 16 patients transplanted for acute leukemia. The influence of several clinical events that could modify the graft fate were also analysed. Our results show that: 1) There was no correlation between the number of infused nucleated cells and granulocyte recovery. 2) There was no correlation between the number of infused CFU-GM and granulocyte regeneration. 3) There were significant differences between the day of engraftment in patients with clinically documented HSV infection compared to patients without infection.
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Abbreviations
- BMT:
-
Bone marrow transplantation
- CFU-GM:
-
Colony forming units granulocytic-macrophagic
- GvHD:
-
Graft versus host disease
- HVS:
-
Herpes virus simplex
- PMN:
-
Polymorphonuclears
- UPN:
-
Unipersonal number
References
Arnold R, Heit W, Heimpel H, Frickofen N, Schmeiser T, Kubanek B (1982) The reconstitution of haemopoietic precursors after bone marrow transplantation. Exp Hematol 10: 79
Boyum A (1968) Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 21: 77–89
Brown DH, Carbone PP (1971) Effects of chemotherapeutic agents on normal mouse bone marrow growth in vitro. Cancer Res 31: 185–190
Faille A, Maraninchi D, Gluckman E, Devergie A, Balitrand N, Ketels F, Dresch C (1981) Granulocyte progenitor compartment after allogeneic bone marrow graft. Scand J Haematol 26: 202–214
Hann JM, Prentice HG, Blacklock HA, Ross M, Brigdem D, Clark A, Burke C, Noone P, Keaney M (1982) Acyclovir prophylaxis of Herpes virus infection in severely immuno-compromised patients. A randomized double blind controlled trial. Exp Hematol 10: 3
Jansen H, Goselink HM, Veenhof WFJ, Blotcamp C, Zwaan FF (1982) Relation of bone marrow graft engraftment and GvHD. Exp Hematol 10: 132
Pike BL, Robinson WA (1970) Human bone marrow colony growth in agar gel. J Cell Physiol 76: 77–84
Spitzer G, Verma DS, Fisher R, Zonder A, Vellekoop L, Litam J, McCredie KB, Dicke KA (1980) The myeloid progenitor cell. Its value in predicting haematopoietic recovery after autologous bone marrow transplantation. Blood 55: 317–323
Storb R, Thomas ED, Buckner CD, Clift RA, Johnson FL, Fefer A, Glucksberg M, Gidlett ER, Lerner KG, Neiman P (1974) Allogeneic marrow grafting for treatment of aplastic anemia. Blood 43: 157–165
Storb R, Thomas ED, Weiden PL, Buckner CD, Clift RA, Fefer A, Fernando LP, Gidlett ER, Goodell BW, Johnson FL, Lerner KG, Neiman P, Sanders JE (1976) Aplastic anemia treated by allogeneic bone marrow transplantation. A report on 49 new cases from Seattle. Blood 48: 841–871
Storb R, Prentice RL, Thomas ED (1977) Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. N Engl J Med 296: 61
Storb R, Thomas ED, Weiden PL, Buckner CD, Clift RA, Fefer A, Goodell BW, Johnson FL, Neiman P, Sanders JE, Singer J (1978) Engraftment of HLA identical marrow in treatment of severe aplastic anemia: results of 110 consecutive transplants. In: Baun SJ, Ledney GD (eds) Experimental hematology today. Springer, Berlin Heidelberg New York, pp 151–155
Thomas ED, Storb R (1970) Technique for human marrow grafting. Blood 36: 507
Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman P, Lerner PE, Glucksberg H, Buckner CD (1975) Bone marrow transplantation. N Engl J Med 292: 895–902
Vogler WR, Minglioli ES, Garwood FA (1973) The effect of methotrexate on granulocytic stem cells and granulopoiesis. Cancer Res 33: 1628–1633
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Torres, A., Alonso, M.C., Gomez-Villagran, J.L. et al. No influence of number of donor CFU-GM on granulocyte recovery in bone marrow transplantation for acute leukemia. Blut 50, 89–94 (1985). https://doi.org/10.1007/BF00321171
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DOI: https://doi.org/10.1007/BF00321171