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Zur Struktur und Funktion des Perineuriums

Structure and function of the perineurium

Die Endigungsweise des Perineuriums vegetativer Nerven

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Summary

The perineurial sheath of small tracheal and mesenteric nerves consists of a layer of flat, basement membrane coated cells. Its ramifications form a complicated layered system, interspersed with collagen fibrils. The tube formed by the thin perineurial sheath ends openly, which affords communication between the respective interstitial spaces.

The mesenteric nerves close to the duodenum as well as the nerves in the vicinity of the tracheal epithelium show no perineurial sheath. Peripheral nerves lacking a perineurial layer seem to be close to their terminations. Their fibers show varicosities containing transmitter vesicles and mitochondria with longitudinally orientated cristae. Our results are compared with those found in thick, multilayered perineurial sheaths and functional differences are discussed.

Zusammenfassung

Das Perineurium kleiner Mesenterial- und Trachealnerven besteht aus einer Lage platter, beiderseits von einer Basalmembran umschlossener Zellen.

Im Bereich von Abzweigungen kleiner Nerven bildet das Perineurium ein gekammertes, stark kollagenfibrillenhaltiges Hüllensystem. Die Endigung der einschichtigen Perineuralhülle hat die Form einer in das Interstitium geöffneten Röhre.

Im ansatznahen Drittel des Mesenteriums und in der Schleimhaut der Trachea wurden ausschließlich perineuriumfreie Nerven gefunden. Es liegt nahe, diese perineuriumfreien Bezirke zu funktionellen Endräumen zusammenzufassen.

In perineuriumfreien Bezirken wird das gehäufte Auftreten von Nervenauftreibungen mit Vesikeln, die Transmittersubstanz enthalten, und Mitochondrion beobachtet.

Die erhobenen Befunde werden mit den an dickem Perineurium gewonnenen Ergebnissen verglichen und diskutiert.

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Literatur

  • Böck, P.: Die Feinstruktur des chromaffinen paraganglionären Gewebes im Plexus suprarenalis des Meerschweinchens. Z. Zellforsch. 105, 389–404 (1970).

    Google Scholar 

  • —, Stockinger, L., Vyslonzil, E.: Die Feinstruktur des Glomus caroticum beim Menschen. Z. Zellforsch. 106, 543–568 (1970).

    Google Scholar 

  • Burkel, W. E.: The relation of perineurium, blood vessels and reticular fibers to tissue space in peripheral nerve. J. Cell Biol. 31, 18a (1966).

    Google Scholar 

  • Causey, G., Palmer, E.: The epineural sheath of a nerve as a barrier to the diffusion of phosphate ions. J. Anat. (Lond.) 87, 36 (1953).

    Google Scholar 

  • Chambers, R., Zweifach, B. W.: Intercellular cement and capillary permeability. Physiol. Rev. 27, 436–463 (1947).

    Google Scholar 

  • Clara, M., Özer, N.: Untersuchungen über die sogenannte Nervenscheide. Acta neuroveg. (Wien) 20, 1–18 (1959).

    Google Scholar 

  • Clementi, F., Palade, G. E.: Intestinal capillaries. II. Structural effects of EDTA and histamin. J. Cell Biol. 42, 706–715 (1969).

    Google Scholar 

  • Cravioto, H.: The perineurium as a diffusion barrier-ultrastructural correlates. Bull. Los Angeles neurol. Soc. 31, 196–208 (1966).

    Google Scholar 

  • Cresticelli, F.: Nerve sheath as a barrier to the action of certain substances. Amer. J. Physiol. 166, 229 (1951).

    Google Scholar 

  • —, Geissmann, T. A.: Certain effects of antihistamines and related compounds on frog nerve fibres. Amer. J. Physiol. 164, 509 (1951).

    Google Scholar 

  • Falck, B., Hillarp, H., Thieme, G., Torp, A.: Fluorescence of catecholamines and related compounds with formaldehyde. J. Histochem. Cytochem. 10, 348–358 (1962).

    Google Scholar 

  • Gräff, S.: Pathologische Anatomie der Zahnheilkunde. Path.-Anat. der Hals-Nasen-Ohren und Zahnheilkunde, Band II, hrsg. von S. Gräff und K. H. Vosteen. Stuttgart: Gustav Fischer 1961.

    Google Scholar 

  • Jabonero, V.: Beobachtungen über die feinere Innervation der Nickhaut. Z. mikr.-anat. Forsch. 78, 511–556 (1968).

    Google Scholar 

  • Karnovsky. M. J.: A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy (abstr.). J. Cell Biol. 27, 137a (1965a).

  • Key, A., Retzius, G.: Studien in der Anatomie des Nervensystems und des Bindegewebes, Band II, p. 100ff. Stockholm: Norstedt und Sönder 1876.

    Google Scholar 

  • Knoche, H.: Morphologisch-experimenteller Beitrag zum lichtmikroskopischen Bau des vegetativen Nervensystems. II. Mitt.: Die Endigungsweise postganglionärer Nervenfasern. Z. Zellforsch. 55, 514–556 (1961).

    Google Scholar 

  • Krnjevic, K.: The connective tissue of frog sciatic nerve. Quart. J. exp. Physiol. 39, 55–71 (1954a).

    Google Scholar 

  • —: Some observations on perfused frog sciatic nerve. J. Physiol. (Lond.) 123, 338–356 (1954b).

    Google Scholar 

  • —: The distribution of Na+ and K+ in cat nerves. J. Physiol. (Lond.) 128, 473–488 (1955).

    Google Scholar 

  • Laidlaw, G. F.: Silverstaining of the endoneural fibres of the cerebrospinal nerve. Amer. J. Path. 6, 435–443 (1930).

    Google Scholar 

  • Lang, J.: The connective tissue and the nerve vessels. Z. Anat. Entwick.-Gesch. 123, 61–79 (1962).

    Google Scholar 

  • Lehmann, H. J.: Über Struktur und Funktion der perineuralen Diffusionsbarriere. Z. Zellforsch. 46, 223–241 (1957).

    Google Scholar 

  • —: Die Nervenfaser. In: Handbuch der mikr.-anat. Anatomie der Menschen. Bd. 4/4, p. 515ff, hrsg. von W. Bargmann. Berlin-Göttingen-Heidelberg: Springer 1959.

    Google Scholar 

  • Lorente De No, R.: A study of nerve physiology, vol. I., p. 21ff. hrsg. von J. F. Fulton: Rockefeller Inst. 1947.

  • —: The ineffectiveness of the connective tissue sheath of nerve as a diffusion barrier. J. cell comp. Physiol., Suppl. 35, 195–240 (1950).

    Google Scholar 

  • —: Observations of the properties of the epineurium of the frog nerve. Cold Spr. Harb. Symp. quant. Biol. 17, 299–315 (1952).

    Google Scholar 

  • Maddrell, S. H. P., Treherne, J. E.: The ultrastructure of the perineurium in two insects species. J. Cell Sci. 2, 119–127 (1967).

    Google Scholar 

  • Majno, G., Palade, G. E.: Studies on inflammation. I. The effect of histamin and serotonine on vascular permeability: An electron microscopic study. J. biophys. biochem. Cytol. 11, 571–605 (1961).

    Google Scholar 

  • Martin, K. H.: Untersuchungen über die perineurale Diffusionsbarriere an gefriergetrockneten Nerven. Z. Zellforsch. 64, 404–428 (1964).

    Google Scholar 

  • Mende, Th., J., Chambers, E. L.: Studies on solute transfer in the vascular endothelium. J. biophys. biochem. Cytol. 4, 319–322 (1958).

    Google Scholar 

  • Millesi, J.: Persönliche Mitteilung.

  • Nicely, M.: Measurement of the potential difference on the connective tissue sheath of the frog nerve. Experientia (Basel) 11, 199 (1955).

    Google Scholar 

  • Ono, M.: Electron microscopic observations on the ganglia of Auerbach's plexus and autonomic nerve endings in muscularis externa of the mouse small intestine. Sapporo Med. J. 32, 56–74 (1967).

    Google Scholar 

  • Pease, D. C., Quilliam, T. A.: Electron microscopy of the Paccinian corpuscle. J. biophys. biochem. Cytol. 3, 331–342 (1957).

    Google Scholar 

  • Pischinger, A.: Die vegetativen Grundlagen des Herdgeschehens. Öst. Z. Stromat. 60, 294–331 (1963).

    Google Scholar 

  • —: Zur Grundlegung unspezifischer Behandlungsweisen. Phys. Med. Rehab. 9, 1–6 (1969).

    Google Scholar 

  • Plenk, H.: Die Schwann'sche Scheide der markhaltigen Nervenfasern. Z. mikr.-anat. Forsch. 36, 191–214 (1934).

    Google Scholar 

  • Plenk, jun. H., Raab, H.: Die Nerven der menschlichen Gingiva. 2. Mitt. Z. mikr.-anat. Forsch. (im Druck).

  • Polacek, P., Halata, Z.: Beziehung der Kapsel der Nervenendigungen zu den Hüllen des Nervensystems. Scrip. Med. 38, 73–83 (1965).

    Google Scholar 

  • Ramsay, J. A.: The excretory system of the stick insect Dixippus morosus. J. exp. Biol. 32, 183–199 (1955).

    Google Scholar 

  • Retzius, G.: Was ist die Henlesche Scheide der Nervenfasern? Anat. Anz. 15, 140 (1898).

    Google Scholar 

  • Robertson, J. D.: The ultrastructure of a reptilian myoneural junction. J. biophys. biochem. Cytol. 2, 381–402 (1956).

    Google Scholar 

  • —: Electron microscopy of the motor end plate and the neuromuscular spindle. Amer. phys. Med. 39, 1–43 (1960).

    Google Scholar 

  • Röhlich, P.: Polarisationsoptische Untersuchungen an der Diffusionsbarriere peripherer Nerven. Z. mikr.-anat. Forsch. 62, 114–124 (1956).

    Google Scholar 

  • —, Knoop, A.: Elektronenmikroskopische Untersuchungen an den Hüllen des Nervus ischiadicus der Ratte. Z. Zellforsch. 53, 299–312 (1961).

    Google Scholar 

  • Salzer, G. M., Stockinger, L., Zenker, W.: Die Ultrastruktur des juxtaoralen Organes der Ratte. Z. Zellforsch. 62, 829–854 (1964).

    Google Scholar 

  • Schröder, J. M., Seifert, K. E.: The ultrastructure of the perineurium in nerve. Congress of Electron Microscopy 1968. Abstracts of Papers presented at the 4th European Regional conference in Rome, Sept. 1968, vol. II, pp 549–550.

  • Shanthtaveerappa, T. R., Bourne, G. H.: The “perineural epithelium” a metabolically active continous protoplasmic cell barrier surrounding the peripheral nerve fasciculi. J. Anat. (Lond.) 96, 527–537 (1962).

    Google Scholar 

  • —: Demonstration of perineural epithelium in whale and shark peripheral nerves. Nature (Lond.) 197, 702–703 (1963).

    Google Scholar 

  • —: The perineural epithelium: Nature and significance. Nature (Lond.) 199, 577–579 (1963a).

    Google Scholar 

  • —: Demonstration of perineural epithelium in vagus nerve. Acta anat. (Basel) 52, 95–100 (1963b).

    Google Scholar 

  • —: New observations on the structure of the Paccinian corpuscle and its relation to the perineural epithelium of peripheral nerves. Amer. J. Anat. 112, 97–109 (1963c).

    Google Scholar 

  • —: The perineural epithelium of sympathetic nerves and ganglia and its relation to the piaarachnoid of the central nervous system and perineural epithelium of the peripheral nervous system. Z. Zellforsch. 61, 742–753 (1964a).

    Google Scholar 

  • —: The effects of transsection of the nerve trunk of the perineural epithelium with special reference to its role in nerve degeneration and regeneration. Anat. Rec. 150, 35–50 (1964b).

    Google Scholar 

  • Somberg, H. M.: The relation of the spinal subarachnoidal and perineural spaces. J. Neuropath. 6, 166–171 (1947).

    Google Scholar 

  • Speransky, A. D.: Grundlagen der Theorie der Medizin (Arbeitsgem. Med. Verl.), p. 83ff. Berlin: Dr. Werner Saenger 1950.

    Google Scholar 

  • Stockinger, L.: Nervenabschnitte ohne Perineurium. Acta anat. (Basel) 60, 244–252 (1965).

    Google Scholar 

  • Sunderland, S., Bardley, K. C.: The perineurium of peripheral nerves. Anat. Rec. 113, 124–141 (1952).

    Google Scholar 

  • Treherne, J. E.: The distribution and exchange of some iones and molecules in the central nervous system of Periplaneta americana. J. exp. Biol. 39, 193–217 (1962).

    Google Scholar 

  • Waggener, J. D., Bunn, S. M., Beggs, J.: The diffusion of ferritine within the peripheral nerve sheath: an electron microscopy study. J. Neuropath. exp. Neurol. 24, 430–443 (1965).

    Google Scholar 

  • Weiss, P.: Endoneural edema in constricted nerve. Anat. Rec. 86, 491–522 (1943).

    Google Scholar 

  • —, Hsi Wang, Tailor, A. C., Mc Edds, V. jun.: Proximodistal fluid convection in the endoneural spaces of peripheral nerves demonstrated by colored and radioactive tracers. Amer. J. Physiol. 143, 521–540 (1945).

    Google Scholar 

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  1. Histologisch-Embryologisches Institut der Universität Wien, Deutschland

    D. Kerjaschki & L. Stockinger

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  1. D. Kerjaschki
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  2. L. Stockinger
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Diese Untersuchung wurde mit dankenswerter Unterstützung durch den Fonds zur Förderung der wissenschaftlichen Forschung durchgeführt.

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Kerjaschki, D., Stockinger, L. Zur Struktur und Funktion des Perineuriums. Z. Zellforsch. 110, 386–400 (1970). https://doi.org/10.1007/BF00321149

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