Summary
Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.
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Supported by Grant CNR n° 84.00553.44 Project Oncology
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Fontana, L., De Rossi, G., De Sanctis, G. et al. Decreased NK activity in hairy cell leukemia (HCL): An analysis at the cellular level. Blut 53, 107–113 (1986). https://doi.org/10.1007/BF00321093
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DOI: https://doi.org/10.1007/BF00321093