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Hepatocellular carcinoma and focal nodular hyperplasia associated with norethandrolone-therapy: A case report

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Summary

A 33-year-old woman was treated for severe aplastic anemia with norethandrolone over a period of four years, with a cumulative dose of 25 g. In the fifth year of therapy two intrahepatic tumors were detected and were classified as hepatocellular carcinoma and as focal nodular hyperplasia, respectively.

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References

  1. Anthony PP (1975) Hepatoma associated with androgenic steroids. Lancet 7908: 685

    Google Scholar 

  2. Boyd PR, Mark GJ (1977) Multiple hepatic adenomas and a hepatocellular carcinoma in a man on oral methyl testosterone for eleven years. Cancer 40: 1765

    Google Scholar 

  3. Chopra S, Edelstein A, Koff RS, Zimelman AP, Lacson A, Neiman RS (1978) Peliosis hepatis in hematologic disease. JAMA 240: 1153

    Google Scholar 

  4. Edmondson HA, Henderson B, Benton B (1976) Liver cell adenomas associated with use of oral contraceptives. N Engl J Med 294: 470

    Google Scholar 

  5. Farrel GC, Uren RF, Perkins KW, Joshua De, Bairs PJ, Kronenberg H (1975) Androgen induced hepatoma. Lancet 7904: 430

    Google Scholar 

  6. Goldfarb S (1976) Sex hormones and hepatic neoplasia. Cancer Res 36: 2584–2588

    Google Scholar 

  7. Gordon BS, Wolf J, Krause T, Shai F (1960) Peliosis hepatis and cholestasis following administration of norethandrolone. Am J Clin Pathol 33: 156

    Google Scholar 

  8. Johnson FL, Lerner KG, Siegel M, Thomas ED, Feagler JR, Majerus PW, Hartman JR (1972) Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet 7790: 1273

    Google Scholar 

  9. Leevy CM, Cherrick GR, Davidson CS (1961) Observations on norethandrolone-induced abnormalities in plasma decay of sulfobromophtalein and indocyanine green. J Lab Clin Med 57: 918

    Google Scholar 

  10. Mays T, Christopherson WM, Mahr ME, Williams HC (1976) Hepatic changes in young women ingesting contraceptive steroids. JAMA 235: 730

    Google Scholar 

  11. Najean Y (1981) For Joint group for the study of aplastic and refractory anemias Long-term follow-up in patients with aplastic anemia. Am J Med 71: 543

    Google Scholar 

  12. Saheb F (1980) Absence of peliosis hepatis in patients receiving testosterone-enanthat. Hepatogastroenterology 27: 432

    Google Scholar 

  13. Scheuer A, Lehmann FG (1977) Lebertumoren bei Therapie mit Kontrazeptiva und Anabolika. Internist 18: 208

    Google Scholar 

  14. Scheuer A, Gerdes H, Lehmann FG (1979) Anabolika und Lebertumoren. Dtsch Med Wochenschr 104: 779

    Google Scholar 

  15. Speck B, Gratwohl A, Nissen C, Leibundgut U, Ruggero D, Osterwalder B, Burri HP, Cornu P, Jeannet M (1981) Treatment of severe aplastic anemia with antilymphocyte globulin or bone marrow transplantation. Br Med J 282: 860

    Google Scholar 

  16. Speck B, Gratwohl A, Nissen C, Osterwalder B, Signer E, Jeannet M (1984) Treatment of severe aplastic anemia. In: Aplastic anemia: stem cell biology and advances in treatment. Alan R Liss, Inc, New York, p 249

    Google Scholar 

  17. Treuner J, Niethammer D, Flach A, Fischbach H, Schenk W (1980) Hepatozelluläres Karzinom nach Oxymetholonbehandlung. Med Welt 31: 952

    Google Scholar 

  18. Tucker RA (1982) Drugs and liver disease: a tabular compilation of drugs and the histopathological changes that can occur in the liver. Drug Intell Clin Pharm 76: 569

    Google Scholar 

  19. Westaby D, Portman B, Williams R (1983) Androgen related primary hepatic tumors in non-Fanconi patients. Cancer 51: 1947

    Google Scholar 

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Serke, S., Dienemann, D., Speck, B. et al. Hepatocellular carcinoma and focal nodular hyperplasia associated with norethandrolone-therapy: A case report. Blut 52, 111–116 (1986). https://doi.org/10.1007/BF00321073

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  • DOI: https://doi.org/10.1007/BF00321073

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