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Prognostic significance of chromosome analysis in de novo acute myeloid leukemia (AML)

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Summary

Between 1981 and 1986 cytogenetic studies of bone marrow and/or blood cells in 139 patients with de novo acute myeloid leukemia (AML) were performed. The overall incidence of chromosomal aberrations was 53%, and this was not significantly influenced by sex, age nor the FAB classification. The aberrations most often found were: complex anomalies (n=13), t(8; 21) (n=10), trisomy 8 (n=9), monosomy 7 (n=6), monosomy 5, 5q-, trisomy 11, 12p- (n=4) and trisomy 6, 11q-, inv [16] (n=3). The prognostic significance of chromosomal findings was evaluated in 112 patients treated by combination chemotherapy. The chromosomal status NN, AN, AA did neither significantly influence complete remission rate (NN: 68%, AN: 71%, AA: 60%) nor mean survival (NN: 24, AN: 26.6, AA: 35.6 months). On the other hand, certain types of chromosomal anomalies were of prognostic value. CR was obtained in all 10 patients with t(8; 21) but only in 2 out of 9 patients with complex aberrations. Median duration of CR in patients with t(8; 21) was significantly longer than in patients with a normal karyotype (30 vs 7 months).

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References

  1. Alimena G, Dallapiccola B, De Cuia MR, Gallo E, Gastaldi R, Nanni M, Franchi A, Mandelli F (1984) Cytogenetic findings in acute promyelocytic leukaemia. A report of 25 cases. Scand J Haematol 33: 135–143

    Google Scholar 

  2. Benedict WF, Lange M, Greene J, Derencsenyi A, Alfi OS (1979) Correlation between prognosis and bone marrow chromosomal patterns in children with acute nonlymphocytic leukemia: similarities and differences compared to adults. Blood 54: 818–823

    Google Scholar 

  3. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) French-American-British (FAB) Cooperative Group: Proposals for the classification of the acute leukaemias. Br J Haematol 33: 451–458

    Google Scholar 

  4. Berger R, Bernheim A, Daniel MT, Valensi F, Sigaux F, Flandrin G (1982) Cytologic characterization and significance of normal karyotypes in t(8; 21) acute myeloblastic leukemia. Blood 59: 171–178

    Google Scholar 

  5. Berger R, Bernheim A, Flandrin G, Daniel MT, Valensi F, Ochoa MH, Marty M, Schaison G, Boiron M (1983) Valeur pronostique des anomalies chromosomiques dans les leucémies aiguës non lymphoblastiques. Nouv Rev Fr Hématol 25: 87–90

    Google Scholar 

  6. Bernard P, Reiffers J, Lacombe F, Dachary D, David B, Boisseau MR, Broustet A (1982) Prognostic value of age and bone marrow karyotype in 78 adults with acute myelogenous leukemia. Cancer Genet Cytogenet 7: 153–163

    Google Scholar 

  7. Bernstein R, Pinto MR, Morcom G, Macdougall LG, Bezwoda W, Dukes I, Penfold G, Mendelow B (1982) Karyotype analysis in acute nonlymphocytic leukemia (ANLL): comparison with ethnic group, age, morphology, and survival. Cancer Genet Cytogenet 6: 187–199

    Google Scholar 

  8. Brodeur GM, Williams DL, Kalwinsky DK, Williams KJ, Dahl GV (1983) Cytogenetic features of acute nonlymphoblastic leukemia in 73 children and adolescents. Cancer Genet Cytogenet 8: 93–105

    Google Scholar 

  9. Büchner T, Urbanitz D, Emmerich B, Fischer JT, Fülle HH, Heinecke A, Hossfeld DK, Koeppen KM, Labedzki L, Löffler H, Nowrousian MR, Pfreundschuh M, Pralle H, Rühl H, Wendt FC for the AML Cooperative Group (1982) Multicentre study on intensified remission induction therapy for acute myeloid leukemia. Leukemia Res 6: 827–831

    Google Scholar 

  10. Castaigne S, Daniel MT, Tilly H, Herait P, Degos L (1983) Does treatment with ARA-C in low dosage cause differentiation of leukemic cells? Blood 62: 85–86

    Google Scholar 

  11. Creutzig U, Ritter J, Riehm H, Langermann HJ, Henze G, Kabisch H, Niethammer D, Jürgens H, Stollmann B, Lasson U, Kaufmann U, Löffler H, Schellong G (1985) Improved treatment results in childhood acute myelogenous leukemia: a report of the German Cooperative Study AML-BFM-78. Blood 65: 298–304

    Google Scholar 

  12. Ellison RR, Holland JF, Weil M, Jacquillat C, Boiron M, Bernard J, Sawitsky A, Rosner F, Gussoff B, Silver RT, Karanas A, Cuttner J, Spurr CL, Hayes DM, Blom J, Leone LA, Haurani F, Kyle R, Hutchison JL, Forcier RJ, Moon JH (1968) Arabinosyl cytosine: a useful agent in the treatment of acute leukemia in adults. Blood 32: 507–523

    Google Scholar 

  13. First International Workshop on Chromosomes in Leukemia. Chromosomes in acute non-lymphocytic leukemia (1978) Br J Haematol 39: 311–316

    Google Scholar 

  14. Fitzgerald PH, Morris CM, Fraser GJ, Giles LM, Hamer JW, Heaton DC, Beard MEJ (1983) Nonrandom cytogenetic changes in New Zealand patients with acute myeloid leukemia. Cancer Genet Cytogenet 8: 51–66

    Google Scholar 

  15. Fourth International Workshop on Chromosomes in Leukemia, 1982 (1984) Overview of association between chromosome pattern and cell morphology, age, sex and race. Cancer Genet Cytogenet 11: 265–274

    Google Scholar 

  16. Fourth International Workshop on Chromosomes in Leukemia, 1982 (1984) Translocation (8; 21) (q22; q22) in acute nonlymphocytic leukemia. Cancer Genet Cytogenet 11: 284–287

    Google Scholar 

  17. Fourth International Workshop on Chromosomes in Leukemia, 1982 (1984) Clinical significance of chromosomal abnormalities in acute nonlymphoblastic leukemia. Cancer Genet Cytogenet 11: 332–350

    Google Scholar 

  18. Gustavson A, Mitelman F, Olofsson T, Olsson I (1984) The relationship between growth in agar, karyotype and prognosis in acute leukaemia. Scand J Haematol 32: 351–363

    Google Scholar 

  19. Hagemeijer A, Hählen K, Abels J (1981) Cytogenetic follow up of patients with nonlymphocytic leukemia. II. Acute nonlymphocytic leukemia. Cancer Genet Cytogenet 3: 109–124

    Google Scholar 

  20. Hagemeijer A, Hählen K, Sizoo W, Abels J (1982) Translocation (9; 11) (p21; q23) in three cases of acute monoblastic leukemia. Cancer Genet Cytogenet 5: 95–105

    Google Scholar 

  21. Hiddemann W, Kreutzmann H, Ludwig WD, Aul HC, Donhuijsen-Ant R, Lengfelder E, Büchner Th (1985) Mitoxantrone and high-dose cytarabine in refractory adult acute myeloid leukemia. Lancet 2: 508–509

    Google Scholar 

  22. Holmes R, Keating MJ, Cork A, Broach Y, Trujillo J, Dalton WT, McCredie KB, Freireich EJ (1985) A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv (16) (p13; q22). Blood 65: 1071–1078

    Google Scholar 

  23. ISCN (1978) An international system for human cytogenetic nomenclature. Cytogenet Cell Genet 21: 309–404

    Google Scholar 

  24. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481

    Google Scholar 

  25. Larson RA, Le Beau MM, Vardiman JW, Testa JR, Golomb HM, Rowley JD (1983) The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia: a 12-year study (1970–1982). Cancer Genet Cytogenet 10: 219–236

    Google Scholar 

  26. Lawler SD, Summersgill B, MacClink HD, McElwain TJ (1980) Cytogenetic follow-up study of acute non-lymphocytic leukaemia. The Leukaemia Unit of the Royal Marsden Hospital. Br J Haematol 44: 395–405

    Google Scholar 

  27. Le Beau MM, Larson RA, Bittner MA, Vardiman JW, Golomb HM, Rowley JD (1983) Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Engl J Med 309: 630–636

    Google Scholar 

  28. Li YS, Hayhoe FGJ (1983) Correlation between chromosomal pattern, cytological subtypes, response to therapy, and survival in acute myeloid leukaemia. Scand J Haematol 30: 265–277

    Google Scholar 

  29. Michaux JL, van den Berghe H (1982) Correlation of clinical and cytogenetic parameters in 203 adult patients with ANLL. 3rd International Symposium on Therapy of Acute Leukemias. Rome, 11–14 December, 1982

  30. Misawa S, Hogge DE, Oguma N, Wiernick PH, Test JR (1986) Detection of clonal karyotypic abnormalities in most patients with acute non-lymphocytic leukemia examined using short-term culture techniques. Cancer Genet Cytogenet 22: 239–251

    Google Scholar 

  31. Mitelman F, Nilsson PG, Brandt L, Alimena G, Gastaldi R, Dallapiccola B (1981) Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia. Cancer Genet Cytogenet 4: 197–214

    Google Scholar 

  32. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35: 1–39

    Google Scholar 

  33. Philip P, Jensen MK, Killmann SAa, Drivsholm A, Hansen NE (1978) Chromosomal banding patterns in 88 cases of acute nonlymphocytic leukemia. Leuk Res 2: 201–212

    Google Scholar 

  34. Prigogina EL, Fleischmann EW, Puchkova GP, Mayakova SA, Volkova MA, Protasova AK, Frenkel MA (1986) Chromosomes in acute nonlymphocytic leukemia. Hum Genet 73: 137–146

    Google Scholar 

  35. Ritter J, Creutzig U, Schellong G (1986) Risikogruppen bei der akuten, nicht lymphatischen Leukämie im Kindesalter. Analyse der Ergebnisse der Kooperativen Therapiestudien AML-BFM 78 und 83. Onkologie 9: 78–82

    Google Scholar 

  36. Sakurai M, Sandberg AA (1973) Prognosis of acute myeloblastic leukemia: chromosomal correlation. Blood 41: 93–104

    Google Scholar 

  37. Seabright M (1971) A rapid banding technique for human chromosomes. Lancet 2: 971–972

    Google Scholar 

  38. Siegel S (1956) Nonparametric statistics for the behavioral sciences, International Student edn, McGraw-Hill, New York

    Google Scholar 

  39. Takeuchi J, Ohshima T, Amaki I (1981) Cytogenetic studies in adult acute leukemias. Cancer Genet Cytogenet 4: 293–302

    Google Scholar 

  40. Tricot G, Broeckaert-van Orshoven A, Casteels-van Daele M, van der Berghe H (1981) 8/21 Translocation in acute myeloid leukaemia. Scand J Haematol 26: 168–176

    Google Scholar 

  41. Trujillo JM, Cork A, Ahearn MJ, Youness EL, McCredie KB (1979) Hematologic and cytologic characterization of 8/21 translocation acute granulocytic leukemia. Blood 53: 695–706

    Google Scholar 

  42. Weinstein HJ, Mayer RJ, Rosenthal DS, Camitta BM, Coral FS, Nathan DG, Frei III E (1980) Treatment of acute myelogenous leukemia in children and adults. N Engl J Med 303: 473–480

    Google Scholar 

  43. Yunis JJ, Brunning RD, Howe RB, Lobell M (1984) High resolution chromosomes as an independent prognostic indicator in adult acute nonlymphocytic leukemia. N Engl J Med 311: 812–818

    Google Scholar 

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Authors and Affiliations

  1. Department of Oncology and Hematology, University Clinic, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    H. J. Weh, D. Seeger, S. Suciu & D. K. Hossfeld

  2. Department of Hematology, St. Georg Hospital, D-2000, Hamburg, Federal Republic of Germany

    R. Kuse & R. Hoffmann

  3. Department of Hematology, Pediatric University Clinic, D-2000, Hamburg, Federal Republic of Germany

    H. Kabisch

  4. Department of Hematology and Oncology, Pediatric University Clinic, D-4400, Münster, Federal Republic of Germany

    J. Ritter

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  1. H. J. Weh
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  2. R. Kuse
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  3. R. Hoffmann
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Weh, H.J., Kuse, R., Hoffmann, R. et al. Prognostic significance of chromosome analysis in de novo acute myeloid leukemia (AML). Blut 56, 19–26 (1988). https://doi.org/10.1007/BF00321055

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  • DOI: https://doi.org/10.1007/BF00321055

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