Summary
To date, 327 cases of variant Philadelphia translocations found in chronic myeloid leukemia have been described. A statistical analysis using the Monte Carlo simulation was performed to determine which chromosomal bands were preferentially involved in variant Philadelphia translocations. The results showed that twenty-eight bands were significantly rearranged (P<0.05).
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References
Caspersson T, Gahrton G, Lindsten J, Zech L (1970) Identification of the Ph chromosome as a number 22 by quinacrine mustard fluorescence analysis. Exp Cell Res 63: 238–240
De Braekeleer M, Smith B, Lin CC (1985) Fragile sites and structural rearrangements in cancer. Hum Genet 69: 112–116
De Braekeleer M, Smith B, Lin CC (1986) Variant Philadelphia translocations in chronic myeloid leukemia. The importance of rearrangement of band 9 q 34. Mamm Chrom Newsl. (In press)
Eight International Workshop on Human Gene Mapping, Helsinki Conference (1985) Human Gene Mapping 8: report of the committee on chromosome rearrangements in neoplasia and fragile sites. Cytogenet Cell Genet 40: 490–535
ISCN (1981) An international system for human cytogenetic nomenclature — High resolution banding. Cytogenet Cell Genet 31: 1–23
Nowell PC, Hungerford DA (1960) A minute chromosome in human chronic granulocytic leukemia. Science 312: 1497
Rowley JD (1973) A new consistent chromosome abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature 243: 290–293
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De Braekeleer, M. Breakpoints in variant Philadelphia translocations in chronic myeloid leukemia. Blut 53, 301–304 (1986). https://doi.org/10.1007/BF00320888
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DOI: https://doi.org/10.1007/BF00320888