Summary
A case of acquired refractory anaemia with excess of blasts (RAEB) of the promegakaryoblastic type is described. The promegakaryoblastic origin was demonstrated by means of ultrastructural cytochemistry (platelet peroxidase) and immunological methods. The blasts were also 5′-Nucleotidase positive. After a stable course over 2,5 years the patient died from hematological failure, his marrow demonstrating a high degree of fibrosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bain B, Catovsky D, O'Brien M, Spiers ASD, Richards MGH (1977) Megakaryoblastic transformation of chronic granulocytic leukaemia. J Clin Pathol 30: 235–242
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnik HR, Sultan C (1985) Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte lineage (M7). Ann Intern Med 103: 460–462
Bollum FJ (1979) Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. Blood 54: 1203–1215
Breton-Gorius J, Daniel MT, Flandrin G, Kinet-Denoël G (1973) Fine structure and peroxidase activity of circulating micromegakaryoblasts and platelets in a case of acute myelofibrosis. Br J Haematol 25: 331–339
Breton-Gorius J, Reyes F, Vernant JP, Tulliez M, Dreyfus B (1978) The blast crisis of chronic granulocytic leukaemias: megakaryoblastic nature of cells as revealed by the presence of platelet peroxidase — a cytochemical ultrastructural study. Br J Haematol 39: 295–303
Breton-Gorius J, Van Haeke D, Pryzwansky KB, Grichard J, Tabilio A, Vainchenker W, Carmel R (1984) Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukaemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase. Br J Haematol 58: 447–458
Castro-Malaspina H, Rabellino EM, Yen A, Nachman RL, Moore MAS (1981) Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts. Blood 57: 781–787
Castro-Malaspina H, Moore MAS (1982) Pathophysiological mechanisms operating in the development of myelofibrosis: role of megakaryocytes. Nouv Rev Fr Hematol 24: 221–226
El-Mohandes E, Hayhoe FGJ (1983) 5′-Nucleotidase activity of megakaryoblasts in a case of acute megakaryoblastic leukaemia. Br J Haematol 53: 523–526
Vilella R, Lozano T, Milà J, Borche L, Ercilla G, Ordinas T, Vives J (1984) Antiplatelet monoclonal antibody that inhibits ADP and Epinephrin induced aggregation. Thromb Haemost 51: 93–96
Woessner S, Lafuente R, Florensa L (1984) La citología óptica en el diagnóstico hematológico, 2nd edn. Medici, Barcelona
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Woessner, S., Lafuente, R., Florensa, L. et al. Acquired refractory anaemia with excess of blasts of promegakaryoblastic type. Blut 53, 293–299 (1986). https://doi.org/10.1007/BF00320887
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320887