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Modulation of in vitro myelopoiesis by alloreactive T cell clones

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Summary

Regulatory effects of mixed lymphocyte culture (MLC)-derived CD4+ human T cell clones on granulocyte-macrophage colony (CFU-GM) formation by normal bone marrow (BM) were studied in an initial attempt to establish an in vitro model for the negative feedback control of myelopoiesis by alloactivated T cells. This is likely to be of clinical significance in the aberrant control of haematopoiesis during some cases of graft-versus-host disease (GVHD) after allogeneic BM transplantation. Whilst 5 such alloproliferative clones generally failed to suppress CFU-GM, the majority of clones with natural killer (NK)-like activity [10], or those with suppressive activity in MLC [2], regularly and strongly suppressed in this system, reinforcing the view that certain T cells may have potent negative regulatory effects on haematopoiesis.

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Authors and Affiliations

  1. Abteilung II, Medizinische Universitätsklinik, D-7400, Tübingen, Federal Republic of Germany

    F. W. Busch, P. Wernet, P. Meyer, E. M. Schneider & G. Pawelec

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  1. F. W. Busch
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  2. P. Wernet
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  3. P. Meyer
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  4. E. M. Schneider
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  5. G. Pawelec
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This work was supported by Deutsche Forschungsgemeinschaft SFB 120 (Projects A1, A2a and C2)

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Busch, F.W., Wernet, P., Meyer, P. et al. Modulation of in vitro myelopoiesis by alloreactive T cell clones. Blut 52, 305–315 (1986). https://doi.org/10.1007/BF00320794

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  • DOI: https://doi.org/10.1007/BF00320794

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