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In vivo activity of asialo-erythropoietin in combination with asialo-glycoproteins

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Summary

In vitro active asialo-erythropoietin has no effect on hemesynthesis in vivo. Asialo-glycophorin induces a very low 59Fe-uptake rate in heme in exhypoxic polycythemic mice. The combination of asialo-erythropoietin and asialo-glycophorin or asialo-fetuin induced an activation comparable to the activation by native erythropoietin. Obviously the combination of asialo-erythropoietin and tested glycoproteins influence the activity of erythropoiesis-stimulating capacity of asialo-erythropoietin.

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Authors and Affiliations

  1. Department of Pediatric Medicine, University Hospital of Hamburg, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany

    E. Weiland, W. Höppner & F. Bläker

  2. Department of Biochemistry, Institute of Organic Chemistry and Biochemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-2000, Hamburg 13, Federal Republic of Germany

    E. Weiland & W. Thorn

  3. Institute of Organic Chemistry and Biochemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-2000, Hamburg 13, Federal Republic of Germany

    W. Höppner

Authors
  1. E. Weiland
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  2. W. Höppner
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  3. F. Bläker
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  4. W. Thorn
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Supported by the “Stiftung Volkswagenwerk”

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Weiland, E., Höppner, W., Bläker, F. et al. In vivo activity of asialo-erythropoietin in combination with asialo-glycoproteins. Blut 44, 173–175 (1982). https://doi.org/10.1007/BF00320764

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  • DOI: https://doi.org/10.1007/BF00320764

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