Skip to main content

Advertisement

SpringerLink
Log in

Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML)

  • Original Articles
  • Published:
Blut Aims and scope Submit manuscript

Summary

In an attempt to relate karyotype evolution to clinical and hematological data serial chromosomal analyses were performed in 31 patients with chronic myeloid leukemia (CML), both in chronic and acute phases. Our results in Philadelphia chromosome (Ph1)-positive CML are in line with karyotype profiles described in the literature. In addition, we report on chromosomal findings in 4 cases of Ph1-negative disease, one presenting with an iso17q chromosome in the acute phase, an aberration otherwise typical for acute transformation in Ph1-positive CML. The same chromosomal abnormality was observed in a small population of Ph1-negative cells present in one of two patients with mixed Ph1-positive/Ph1-negative CML. The first case of a female patient with the loss of a sex chromosome in Ph1-positive cells is reported. Two patients with unusually long and mild chronic phases despite the presence of trisomy 8 in their karyotypes are described. Our findings suggest that the order of appearance of additional chromosomal changes of CML is of prognostic significance for the progression and the clinical picture of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Alimena G, Brandt L, Dallapiccola B, Mitelman F, Nilsson PG (1979) Secondary chromosome changes in chronic myeloid leukemia: Relation to treatment. Cancer Genet Cytogenet 1: 79

    Google Scholar 

  2. Alimena G, Dallapiccola B, Gastaldi R, Mandelli F, Brandt L, Mitelman F, Nilsson PG (1982) Chromosomal, morphological and clinical correlations in blast crisis of chronic myeloid leukemia. A study of 69 cases. Scand J Haematol 28: 103

    Google Scholar 

  3. Bernstein R, Morcom G, Pinto MR, Menelow B, Dukes I, Penfold G, Bezwoda W (1980) Cytogenetic findings in chronic myeloid leukemia (CML): Evaluation of karyotype, blast morphology, and survival in the acute phase. Cancer Genet Cytogenet 2: 23

    Google Scholar 

  4. Brodsky I, Fuscaldo KE, Kahn SB, Conroy JF (1979) Myeloproliferative disorders: II. CML: Clonal evolution and its role in management. Leuk Res 3: 379

    Google Scholar 

  5. Cervantes F, Rozman C, Ballesta F, Mila M (1982) Prognostic significance of cytogenetical studies in chronic granulocytic leukemia. Scand J Haematol 28: 77

    Google Scholar 

  6. First International Workshop on Chromosomes in Leukemia (1978) Chromosomes in chronic myelogeneous leukemia. Br J Haematol 39: 305

    Google Scholar 

  7. Fuscaldo KE, Brodsky I, Kahn SB, Conroy JF, Marfurt K (1981) Myeloproliferative disorders: III. CML: Further studies on the role of cytogenetics in diagnosis, prognosis and management. Haematologica 66: 461

    Google Scholar 

  8. Gödde E, von Zelewski E (1980) A clone with loss of the Y chromosome in Ph1-positive chronic myelocytic leukemia. Cancer Genet Cytogenet 2: 7

    Google Scholar 

  9. Hagemeijer A, Stenfert Kroeze WF, Abels J (1980) Cytogenetic follow-up of patients with nonlymphocytic leukemia. I. Philadelphia chromosome-positive chronic myeloid leukemia. Cancer Genet Cytogenet 2: 317

    Google Scholar 

  10. Hayata I, Sakurai M, Kakati S, Sandberg AA (1975) The chromosomes and causation of human cancer and leukemia: XIV. Banding studies of chronic myelocytic leukemia, including five unusual Ph1 translocations. Cancer 36: 1177

    Google Scholar 

  11. Koeffler HP, Golde DW (1981) Chronic myelogenous leukemia — new concepts. N Engl J Med 304: 1201, 1269

    Google Scholar 

  12. Kohno S, Abe S, Sandberg AA (1979) The chromosomes in human cancer and leukemia: XXXVIII. Cytogenetic experiance in Ph1-negative chronic myelocytic leukemia (CML). Am J Hematol 7: 281

    Google Scholar 

  13. Marks S, Baltimore D, McCaffrey R (1978) Terminal transferase as predictor of initial responsiveness to vincristine and prednisone in blastic chronic myelogenous leukemia. N Engl J Med 298: 812

    Google Scholar 

  14. Mitelman F, Levan G, Nilsson PG, Brandt L (1976) Non-random karyotypic evolution in chronic myeloid leukemia. Int J Cancer 18: 24

    Google Scholar 

  15. Mitelman F, Levan G (1978) Clustering of aberrations to specific chromosomes in human neoplasms. III. Incidence and geographic distribution of chromosome aberrations in 856 cases. Hereditas 89: 207

    Google Scholar 

  16. Mitelman F, Levan G (1981) Clustering of aberrations to specific chromosomes in human neoplasms. IV. A survey of 1871 cases. Hereditas 95: 79

    Google Scholar 

  17. Motomura S, Konachi O, Shushi K (1976) Progression and prognosis of chronic myelogenous leukemia in the acute stage: Haematologic and cytogenetic aspects. Acta Haematol 56: 78

    Google Scholar 

  18. Oláh E, Kiss A, Jako K (1980) Chromosome abnormalities, clinical and morphological manifestations in metamorphosis of chronic myeloid leukemia. Int J Cancer 26: 37

    Google Scholar 

  19. Oláh E, Rak K (1981) Prognostic value of chromosomal findings in the blast phase of Ph1-positive chronic myeloid leukemia (CML). Int J Cancer 27: 287

    Google Scholar 

  20. Paietta E, Schwarzmeier JD (1981) Phenotypic changes in a case of blast crisis of CML: Characterization by TdT, cytochemistry, and cytogenetics. Scand J Haematol 27: 241

    Google Scholar 

  21. Prigogina EL, Fleischmann EW, Volkova MA, Frenkel MA (1978) Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia. Hum Genet 41: 143

    Google Scholar 

  22. Rowley JD (1978) Chromosome abnormalities in the acute phase of CML. Virchows Arch B [Cell Pathol] 29: 57

    Google Scholar 

  23. Sandberg AA (1978) Chromosomes in the chronic phase of CML. Virchows Arch B [Cell Pathol] 29: 51

    Google Scholar 

  24. Sandberg AA (1980) The leukemias: Chronic granulocytic leukemia. In: The chromosomes in human cancer and leukemia. Elsevier North Holland, Amsterdam, p 183

    Google Scholar 

  25. Second International Workshop on Chromosomes in Leukemia. Cancer Genet Cytogenet 2: 89

  26. Schilling RF, Crowley JJ Prognostic signs in chronic myelocytic leukemia. Am J Hematol 7: 1

  27. Schwarzmeier JD, Haas OA, Paietta E, Fischer P (1982) Chromosomenanalyse und TdT-Bestimmung: Wichtige prognostische Parameter der Blastenkrise der CML. Wien Klin Wochenschr 19: 514

    Google Scholar 

  28. Sokal JE (1980) Significance of Ph1-negative marrow cells in Ph1-positive chronic granulocytic leukemia. Blood 56: 1072

    Google Scholar 

  29. Sonta S, Sandberg AA (1978) Chromosomes and causation of human cancer and leukemia. XXIV. Further studies on karyotypic progression in CML. Cancer 41: 153

    Google Scholar 

  30. Spiers ASD, Goldman JM, Catovsky D, Castello C, Buskard NA, Ga ton DAG (1977) Multiple drug chemotherapy for acute leukemia. The TRAMPCOL regimen: results in 86 patients. Cancer 40: 20

    Google Scholar 

  31. Spiers ASD (1981) Chronic granulocytic leukemia: Present status and future progress. Abstract book, International Society Haematology European and African Division, Sixth Meeting, Athens

  32. Stoll C, Oberling F (1979) Non-random clonal evolution in 45 cases of chronic myeloid leukemia. Leuk Res 3: 61

    Google Scholar 

  33. The Third International Workshop on Chromosomes in Leukemia. Cancer Genet Cytogenet 4: 95

  34. Waddell CC, Brown JA, Zelnick PW (1980) Chronic myelogenous leukemia: Association with 45 XO Philadelphia chromosome karyotype and proloned survival. Arch Int Med 140: 270

    Google Scholar 

  35. Wang HC, Fedoroff S (1972) Banding in human chromosomes treated with trypsin. Nature New Biology 235: 52

    Google Scholar 

  36. Wayne AW, Sharp JC, Joyner MV, Sterndale H, Pulford KAF (1979) The significance of Ph1-mosaicism: A report of six cases of chronic granulocytic leukemia and two cases of acute myeloid leukemia. Br J Haematol 43: 353

    Google Scholar 

  37. Wintrobe MM (1981) Clinical hematology, 8th edn. Lea and Febiger, Philadelphia, p 1565

    Google Scholar 

  38. Wolf DJ, Silver RT, Coleman M (1978) Factors associated with prolonged survival in chronic myeloid leukemia. Cancer 42: 1957

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Anna Kinderspital, Kinderspitalgasse 6, A-1090, Wien, Austria

    O. A. Haas

  2. I. Medizinische Universitätsklinik, Vienna, Austria

    J. D. Schwarzmeier & E. Paietta

  3. Oncological Institute, Medical Academy, Sofia, Bulgaria

    E. Nacheva

  4. Institut für Krebsforschung der Universität Wien, Vienna, Austria

    P. Fischer

Authors
  1. O. A. Haas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. D. Schwarzmeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Nacheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Paietta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haas, O.A., Schwarzmeier, J.D., Nacheva, E. et al. Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML). Blut 48, 33–43 (1984). https://doi.org/10.1007/BF00320715

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00320715

Key words

Search

Navigation