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High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP) clinical effects

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Summary

This study of the effect of high-dose intravenous gammaglobulins with one or two courses of therapy in 18 adults with idiopathic thrombocytopenia purpura showed a platelet rise in thirteen patients. The highest response rates were seen in splenectomized adults. In chronic patients the response was transient only. If therapy was effective, increased values of platelet-associated IgG were reduced, while shortened platelet survival times were prolonged. There was no influence of high-dose gammaglobulins on platelet function. Different 7S-preparations such as β-propiolactone modified Ig, pH 4 treated Ig and reduced and alkylated Ig have comparable effects.

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Authors and Affiliations

  1. Medizinische Universitätsklinik Bonn, Sigmund-Freud-Str. 25, D-5300, Bonn, Federal Republic of Germany

    R. E. Schmidt & C. Bröschen-Zywietz

  2. Institut für Experimentelle Hämatologie und Bluttransfusionswesen, Sigmund-Freud-Str. 25, D-5300, Bonn, Federal Republic of Germany

    U. Budde, G. Schäfer & C. Mueller-Eckhardt

  3. Institut für Klinische Immunologie und Transfusionsmedizin, Gießen, Langhansstr. 7, D-6300, Gießen, Federal Republic of Germany

    R. E. Schmidt, U. Budde, C. Bröschen-Zywietz, G. Schäfer & C. Mueller-Eckhardt

Authors
  1. R. E. Schmidt
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  2. U. Budde
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  3. C. Bröschen-Zywietz
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  4. G. Schäfer
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  5. C. Mueller-Eckhardt
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Supported by the Deutsche Forschungsgemeinschaft (Mu 277/9-4)

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Schmidt, R.E., Budde, U., Bröschen-Zywietz, C. et al. High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP) clinical effects. Blut 48, 19–25 (1984). https://doi.org/10.1007/BF00320713

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  • DOI: https://doi.org/10.1007/BF00320713

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