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Seeblaue Histiozytose bei myelomonozytärer Leukämie — eine erworbene Lipidose?

Seablue histiocytosis in myelomonocytic leukemia — an acquired lipidosis?

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Summary

Seablue histiocytes were seen in the bone marrow and postmortem in the spleen of a patient with chronic myelomonocytic leukemia. Cytochemical and electron microscopic studies established the similarity of these cells to those found in adult Niemann-Pick disease. In comparison to normal spleen tissue the lipid analysis to this patient's spleen indicated a decrease mainly in the triglyceride fraction, whereas the sphingolipids showed a clear increase. The increase of gangliosides was five times, of cerebrosides was three fold, and that of sphingomyelin two fold.

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Authors and Affiliations

  1. Medizinische Klinik, St. Elisabethen-Krankenhaus, D-7980, Ravensburg, Bundesrepublik Deutschland

    Siegmar Mende

  2. Lehrstuhl II, Institut für Physiologische Chemie der Universität Köln, Josef-Stelzmann-Straße 52, D-5000, Köln 41, Bundesrepublik Deutschland

    Ernst Göpfert & Hildegard Debuch

  3. II. Innere Abteilung, Krankenhaus Moabit, Turmstr. 21, D-1000, Berlin 21

    Walther Pribilla

Authors
  1. Siegmar Mende
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  2. Ernst Göpfert
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  3. Hildegard Debuch
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  4. Walther Pribilla
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Mende, S., Göpfert, E., Debuch, H. et al. Seeblaue Histiozytose bei myelomonozytärer Leukämie — eine erworbene Lipidose?. Blut 44, 315–320 (1982). https://doi.org/10.1007/BF00320707

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  • DOI: https://doi.org/10.1007/BF00320707

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