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Unreifzellige Leukämien im fortgeschrittenen Lebensalter

Acute leukemias in elderly patients

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Summary

We conducted an investigation of 186 randomly selected acute adult leukemia patients in order to examine how far age and subtype of leukemia can be correlated with survival rate. The diagnosis of leukemia was established by cytochemical and cytomorphological techniques. There was an increased frequency of acute myelogenic leukemias in older patients. The age group of the 61–90 year old showed a significant decrease in the survival rate, but at the same time in this age group there was a higher frequency of leukemia types with poor prognosis. Early deaths were correlated with advanced age of patients. There were no long time survivors (with survival rates longer than 4 years after diagnosis) above the age of 57.

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Literatur

  1. Abbrederis K, Schmalzl F, Braunsteiner H (1973) Zur Typenverteilung, Alters- und Geschlechtsdisposition der akuten Leukämien des Erwachsenen. Blut 27: 302

    Google Scholar 

  2. Abbrederis K, Schmalzl F (1974) Akute undifferenzierte Leukämie — akute lymphatische Leukämie des Erwachsenen. Med Klin 69: 1364

    Google Scholar 

  3. Abbrederis K (1977) Klinische Relevanz zytochemischer Befunde bei differenzierten myelogenen Leukämien des Erwachsenen. Wien Klin Wochenschr [Suppl 76] 89: 20

    Google Scholar 

  4. Axtell LM, Myers MH, Christine B, Linden G (1974) Trends in survival and classification for patients with leukemia diagnosed 1940–69. J Natl Cancer Inst 53: 375

    Google Scholar 

  5. Bernard J, Weil M, Boiron M, Flandrin G, Gemon MF (1973) Acute promyelocyte leukemia: results of treatment by daunorubicin. Blood 41: 489

    Google Scholar 

  6. Bloomfield CD, Theolodiges A (1973) Acute granulocytic leukemia in elderly patients. JAMA 226: 1190

    Google Scholar 

  7. BMD-Program — 02S (1976) Biomedical computer programs, University of California Press, Berkeley London, p 397

    Google Scholar 

  8. Brandt L, Konyves I (1977) Therapeutic effect of Prednimustin (Leo 1031) in various types of leukemia. Eur J Cancer 13: 393

    Google Scholar 

  9. Brunner KW (1976) Ergebnisse kontrollierter Untersuchungen der zytostatischen Therapie der akuten myeloischen Leukämien. In: Stacher A, Höcker P (eds) Erkrankungen der Myelopoese. Urban u Schwarzenberg, München Berlin Wien

    Google Scholar 

  10. Burge PS, Richards JDM, Thompson DS, Prankerd TAJ, Sare M, Wright P (1975) Quality and quantity of survival in acute myeloid leukemia. Lancet II: 621

    Google Scholar 

  11. Cavalli F (1980) Prognostische Faktoren und Therapie der akuten Leukämie beim Erwachsenen. Huber, Bern Stuttgart Wien

    Google Scholar 

  12. Clarkson BD, Dowling MD, Gee TS, Cunningham ID, Burchenal JH (1975) Treatment of acute leukemia in adults. Cancer 36: 775

    Google Scholar 

  13. Ellison RR, Glidewell O (1975) Prognostic parameters in acute myelocytic leukemia as seen in Acute Leukemia Group B. Advances in the Biosciences 14, Workshop on prognostic factors in human leukemia. Pergamon Press, New York

    Google Scholar 

  14. Enck RE, Bauman AW, Bennet JM (1976) Adult acute leukemia: The Rochester Experience. Arch Intern Med 136: 1256

    Google Scholar 

  15. Gmür J, Gürtler J, Straub PW (1976) Daunomycin-Mono-Therapie bei akuter Promyelozytenleukämie. Schweiz Med Wochenschr 106: 205

    Google Scholar 

  16. Heller A (1979) Zytochemische Diagnostik in der klinischen Hämatologie. Thieme, Stuttgart

    Google Scholar 

  17. Hennekeuser HH (1972) Untersuchungen zur Klassifizierung akuter Leukämien. In: Frick P, Harnack G-A von, Martini GA, Prader A, Wolff HP (Hrsg) Ergebnisse der Inneren Medizin und Kinderheilkunde, Bd 33. Springer, Berlin Heidelberg New York

    Google Scholar 

  18. Huhn D, Thiel E, Rodt H (1980) Classification of normal and malignant lymphatic cells using acid phosphatase and acid esterase. Klin Wochenschr 58: 65

    Google Scholar 

  19. Jehn U, Clemm Ch, Wilmanns W (1981) Behandlungsergebnisse akuter Leukämien im Erwachsenenalter: Kritische Analyse eines unselektionierten Patientengutes. Onkologie 4 (2): 60

    Google Scholar 

  20. Jungi WF, Obrecht JP, Senn HJ (1979) Die akute Leukämie des Erwachsenen. In: Brunner KW, Nagel GA (eds) Internistische Krebstherapie. Springer, Berlin Heidelberg New York

    Google Scholar 

  21. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719

    Google Scholar 

  22. Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50: 163

    Google Scholar 

  23. Mathé G, Pouillart P (1971) Subdivision of classical varieties of acute leukemia. Correlation with prognosis and cure expenctance. Rev Etud Clin Biolog 16: 554

    Google Scholar 

  24. Peterson BA, Bloomfield CD (1977) Treatment of acute non-lymphocytic leukemia in elderly patients. Cancer 40: 647

    Google Scholar 

  25. Peto R, Pike Mc, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1976) Design and Analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer 34: 585

    Google Scholar 

  26. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35: 1

    Google Scholar 

  27. Third national cancer advanced three year report 1969–71 incidence. Biometry Branch, National Cancer Institute, National Institutes of Health. Bethesda. Maryland 20014, DHEW publication No (NIH) 75

  28. Quattrin N, di Girolamo R, Mastrobuoni A, Montuori R, de Rosa L (1976) Therapeutic experience with Daunomycin and Cytarabinoside in acute non lymphoid leukemias according to age and cytologic type. In: Stacher A, Höcker P (eds) Erkrankungen der Myelopoese, Urban u Schwarzenberg, München Berlin Wien

    Google Scholar 

  29. Rai KR, Holland JF, Glidewell OJ (1975) Improvement in remission induction therapy of acute myelocytic leukemia. Proc Am Assoc Cancer Res 16: 265

    Google Scholar 

  30. Reiffers J, Raynal F, Broustet A (1980) Acute myeloblastic leukemia in elderly patients. Treatment and prognostic factors. Cancer 45: 2816

    Google Scholar 

  31. Sauer H, Wilmanns W (1980) Internistische Therapie maligner Erkrankungen. Urban u Schwarzenberg, München Wien Baltimore

    Google Scholar 

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Grünewald, K., Abbrederis, K., Mittermaier, P. et al. Unreifzellige Leukämien im fortgeschrittenen Lebensalter. Blut 44, 289–296 (1982). https://doi.org/10.1007/BF00320703

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