Summary
Two patients with acute lymphocytic leukemia are described in whom G- and R-banding analysis revealed in bone marrow cells a translocation t (4; 11) (q21; q23). The clinical data are compared to the other four cases with t (4; 11) reported so far in the literature. The anomaly seems to be characteristic for ALL. In addition it appears to be associated with a very high number of circumlating blasts and other poor prognostic factors.
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References
Dutrillaux B, Lejeune J (1971) Sur une nouvelle technique d'analyse du caryotype humain. CR Acad Sci (Paris) 272: 2638
Harousseau JL, Tobelem G, Schaison C, Jacquillat Cl (1979) Leucémies aiguës lymphoblastiques hyperleucocytaires. Problèmes d'urgence au cours du traitement initial. Nouv Presse Med 8: 1827
Jacquillat Cl, Weil M, Auclerc MF, Schaison G, Holland JF (1977) Traitement des leucémies aiguës. Nouv Rev Fr Hématol 18: 293
Oshimura M, Freeman AI, Sandberg AA (1977) Chromosomes and causation of human cancer and leukemia. XXVI. Banding studies in acute lymphoblastic leukemia (ALL). Cancer 40: 1161
Seabright M (1971) A rapid banding technique for human chromosomes. Lancet II: 971
Tsukimoto I, Wong KY, Lampkin BC (1976) Surface markers and prognostic factors in acute lymphoblastic leukemia. New Engl J Med 294: 245
Van den Berghe H, David G, Broeckaert-Van Orshoven A, Louwagie A, Verwilghen R, Casteels-Van Daele M, Eggermont E, Eeckels R (1979) A new chromosome anomaly in acute lymphoblastic leukemia (ALL). Hum Genet 46: 173
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Weh, H.J., Hossfeld, D.K. Translocation t (4; 11) in acute lymphocytic leukemia (ALL). Blut 44, 271–274 (1982). https://doi.org/10.1007/BF00320701
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DOI: https://doi.org/10.1007/BF00320701