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Fibrinogen — proteolysis in acute myelogenous leukemia (AML)

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Summary

Fibrinopeptides were measured as direct indices of thrombin, plasmin and elastase in plasma samples obtained from patients with AML. Peptide patterns observed were consistent with spontaneous or drug induced plasmin-specific fibrinogenolysis (AML FAB M 1/3), elastase mediated proteolysis (AML FAB M 3/4) or DIC (AML FAB M 4/5). DIC was also observed in septic, agranulocytotic patients.

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Authors and Affiliations

  1. Zentrum für Innere Medizin am Klinikum der Justus Liebig-Universität Gießen, Klinikstraße 36, D-6300, Gießen, Federal Republic of Germany

    Thomas Eckhardt & Michael Koch

Authors
  1. Thomas Eckhardt
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  2. Michael Koch
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Additional information

This paper is dedicated to the memory of Dr. H. L. Nossel, who most generously supplied reagents for this study

The doctoral thesis of Michael Koch is partly presented in this work

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Eckhardt, T., Koch, M. Fibrinogen — proteolysis in acute myelogenous leukemia (AML). Blut 53, 39–48 (1986). https://doi.org/10.1007/BF00320581

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  • DOI: https://doi.org/10.1007/BF00320581

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