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Thrombosis and atherosclerosis: Regulatory role of interactions among blood components and endothelium

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Summary

Complex interactions among constituents of blood and components of the vessel wall are involved in the pathogenesis of atherosclerosis and its subsequent thrombotic complications. Alterations in the endothelium are central both to the slowly progressive process of atherogenesis and to the acute events leading to thrombotic occlusion. Recent data, obtained by systematic evaluation of chronologic events that occur in diet-induced atherosclerosis, have extended our understanding of interactive processes among endothelium, monocytes, platelets, vascular smooth muscle cells, and humoral hemostatic elements in atherogenesis.

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Abbreviations

ADP:

adenosine diphosphate

APC:

activated protein C

AT III:

antithrombin III

FDP:

fibrin(ogen) degradation products

GP:

glycoprotein

LDL:

low density lipoprotein

PA:

plasminogen activator

PAI:

plasminogen activator inhibitor

PDGF:

platelet-derived growth factor

PF 4:

platelet factor 4

PGI2 :

prostacyclin

T: AT III:

thrombinantithrombin III complex

βTG:

β-thromboglobin

TNF:

tumor necrosis factor

TXA2 :

thromboxane A2

vWF:

von Willebrand factor

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik, Abteilung für Hämatologie, Onkologie und Klinische Immunologie, Universität Düsseldorf, D-4000, Düsseldorf, Federal Republic of Germany

    Rüdiger E. Scharf

  2. Roon Research Center for Arteriosclerosis and Thrombosis, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, 92037, La Jolla, CA, USA

    Laurence A. Harker

Authors
  1. Rüdiger E. Scharf
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  2. Laurence A. Harker
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Additional information

This work was supported in part by the Deutsche Forschungsgemeinschaft (grant Scha 358/1–2) and the National Institutes of Health (grants HL 31950 and RR 00833)

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Scharf, R.E., Harker, L.A. Thrombosis and atherosclerosis: Regulatory role of interactions among blood components and endothelium. Blut 55, 131–144 (1987). https://doi.org/10.1007/BF00320567

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