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Treatment with natural human interferon alpha of a CML-patient with antibodies to recombinant interferon alpha-2 b

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Summary

A patient with Philadelphia-chromosome positive chronic myelogenous leukemia developed interferon antibodies on treatment with recombinant interferon alpha-2 b. Clinically this event corresponded with progressive disease. No cross-reactivity of antibodies with human leukocyte interferon was found by Western blot. Treatment was switched to human leukocyte interferon with an obvious clinical effect: WBC was reduced and platelet count stabilized, but the effect was transient and no hematologic remission was achieved. Human leukocyte interferon may be an alternative in CML-patients with neutralizing antibodies to recombinant interferon alpha.

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Authors and Affiliations

  1. Department Hematology/Oncology, Hannover Medical School, Konstanty-Gutschow-Strasse 8, D-3000, Hannover 61

    M. Freund, G. Exeriede, H. Link, H. J. Wilke & H. Poliwoda

  2. Department Immunology, Hannover Medical School, Konstanty-Gutschow-Strasse 8, D-3000, Hannover 61

    P. von Wussow

  3. German Red Cross Blood Transfusion Service Lower Saxony, Eldagsener Strasse 38, D-3257, Springe 1, Federal Republic of Germany

    J. Knüver-Hopf, H. Mohr & U. Pohl

Authors
  1. M. Freund
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  2. P. von Wussow
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  3. J. Knüver-Hopf
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  4. H. Mohr
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  5. U. Pohl
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  6. G. Exeriede
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  7. H. Link
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  8. H. J. Wilke
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  9. H. Poliwoda
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Freund, M., von Wussow, P., Knüver-Hopf, J. et al. Treatment with natural human interferon alpha of a CML-patient with antibodies to recombinant interferon alpha-2 b. Blut 57, 311–315 (1988). https://doi.org/10.1007/BF00320360

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  • DOI: https://doi.org/10.1007/BF00320360

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