Summary
Seven episodes of adult respiratory distress syndrome, occurring in leukemic patients with longstanding (average 11 days) and severe neutropenia (<0.1×109/l) are described. Pathologocial and clinical data give further support to the view that the complement-neutrophil pathway is not the only mechanism in generating clinical ARDS in leukemia patients.
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References
Ashbaugh DG, Petty TL, Bingelow DB, Levine BE (1967) Acute respiratory distress in adults. Lancet II: 319–323
Boogaerts AM, Roelant C, Zachee P, Verwilghen RL (1986) Complement activation and ARDS during intermittent flow apheresis procedures. Transfusion 26: 82–88
Braude S, Apperley J, Krausz T, Goldman JM, Royston D (1985) ARDS after allogeneic bone marrow transplantation: evidence for a neutrophil-independent mechanism. Lancet I: 1239–1242
Cochrane CG, Spragg R, Revak SD (1983) Pathogenesis of ARDS: Evidence of oxidant activity in BAL fluid. J Clin Invest 71: 754–761
Craddock PR, Hammersmidt DE, Moldow CF, Yamada O, Jacob HS (1979) Granulocyte-aggregation as a manifestation of membrane interactions with complement: possible role in leukocyte margination, micro-vascular occlusion and endothelial damage. Semin Hematol 16: 140–147
Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacob HS (1977) Hemodialysis leukopenia: pulmonary vascular leukostasis resulting from complement activation by dialyser cellophane membrane. J Clin Invest 59: 879–888
Craddock PR, Hammersmidt DE, White JG, Dalmasso AP, Jacob HS (1977) C5a induced granulocyte-aggregation in vitro: a possible mechanism of leukostasis and leukopenia. J Clin Invest 60: 260–264
Dinarelloca, Cannon JG, Wolff SM (1988) New concepts in the pathogenesis of fever. Rev Inf Diseases 10: 168–189
Hammersmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS (1980) Association of complement activation and elevated plasma C5a with ARDS: pathophysiological relevance and and possible prognostic value. Lancet I: 947–949
Jacob HS, Craddock PR, Hammersmidt DE, Moldow CF (1980) Complement induced granulocyte aggregation: an unsuspected mechanism of disease. N Engl J Med 302: 789–794
Lamy M, Fallat RJ, Koeniger E, Dietrich HP, Ratcliff JL, Eberhardt RC, Tucker HJ, Donald Hill J (1976) Pathologic features and mechanisms of hypoxema in ARDS. Am Rev Respir Dis 114: 267
Laufe MD, Simon RH, Flint A, Keller JB (1986) ARDS in neutropenic patients. Am J Med 80: 1022–1026
Lung Program (1972) National Heart and Lung Institute, Respiratory Diseases. Task force on problems, research approaches, needs. 171. (DHEW publication NIH 73-432) Government Printing Office, Washington DC
Murray JF (1977) Mechanisms of acute respiratory failure. Am Rev Respir Dis 115: 1071–1078
Ognibene FP, Martin JE, Parker MM, Schlesinger T, Roach P, Burch C, Shelhamer JH, Parillo JE (1986) ARDS in patients with severe neutropenia. N Engl J Med 315: 547–551
Whitcomb ME (1973) Drug induced lung disease. Chest 63: 418–422
Yamada O, Moldow CF, Sachs T, Boogaerts MA, Jacob HS (1981) Deleterious effects of endotoxin on cultured endothelial cells: an in vitro model of vascular injury. Inflammation 5: 115–126
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Vansteenkiste, J.F., Boogaerts, M.A. Adult respiratory distress syndrome in neutropenic leukemia patients. Blut 58, 287–290 (1989). https://doi.org/10.1007/BF00320168
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DOI: https://doi.org/10.1007/BF00320168