Summary
An unusual case of chronic myelocytic leukemia (CML) is described that presented leukocytosis at onset (720×109/l), symptoms of stasis, organomegaly, and a conspicuous infiltration of leukemic cells from the pelvis to the right popliteal cavity. As initial therapy and in addition to chemotherapy, six therapeutic leukapheresis treatments (TL) were performed and the patient showed dramatic symptomatic improvement with reduction in leukocytosis (97×109/l), organomegaly, and tissue infiltration.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Eisenstaedt RS, Berkman EM (1978) Rapid cytoreduction in acute leukemia. Transfusion 18: 113–115
Klein GH (1983) Therapeutic cytapheresis. In: Kolins J, Jones JM (eds) Therapeutic apheresis. AABB, Arlington Virginia, pp 23–34
Lowenthal RM, Buskard NA, Park J, Goldman JM (1975) Intensive leukapheresis as initial therapy for chronic granulocytic leukemia. Blood 46: 835–844
Maher JF, Rath CE, Schreiner GE (1969) Hyperuricemia complicating leukemia. Arch Intern Med 123: 198–200
Marti GE, Folks T, Longo DL, Klein H (1983) Therapeutic cytapheresis in chronic lymphocytic leukemia. J Clin Apheresis 1: 243–248
Steeper TA, Smith JA, McCullough (1985) Therapeutic cytapheresis using the Fenwal CS 3000 blood cell separator. Vox Sang 48: 193–200
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pagani, A., Ippoliti, G., Perseghin, P. et al. An unusual case of chronic myelocytic leukemia characterized by a conspicuous tissue infiltration treated with leukapheresis. Blut 56, 103–105 (1988). https://doi.org/10.1007/BF00320011
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320011