Summary
A case of fatal intracranial hemorrhage is reported in an eleven year old girl with acute idiopathic thrombocytopenic purpura following a viral infection. The patient was randomized to the IgG-arm of the ITP therapy study. Immunoglobulin administration was not followed by a raise of the thrombocyte count. Neither the IgG therapy nor intensive therapeutic measurements were able to prevent the fatal course of cerebral hemorrhage in this case. Pathological and immunological findings indicate that our patient suffered from a fulminant ITP which must be considered as a part of a still active viral disease.
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Imbach P, Barandun S, d'Apuzzo V, Baumgartner C, Hirt A, Morell A, Rossi E, Schoeni M, Vest M, Wagner HP (1981) Hig dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1: 1128
McWilliams NB, Maurer HM (1979) Acute idiopathic thrombocytopenic purpura in children. Am J Hematol 7: 87
Mueller-Eckhardt C, Mahn I, Schulz G, Mueller-Eckhardt G (1978) Detection of platelet autoantibodies by a radioactive anti-immunoglobulin test. Vox Sang 35: 357
Schneider W, Schnaidt M (1981) The platelet adhesion immunofluorescence test: a modification of the platelet suspension immunofluorescence test. Blut 43: 381
Woerner SJ, Abildgaard CF, French BN (1981) Intracranial hemorrhage in children with idiopathic thrombocytopenic purpura. Pediatrics 67: 453
Yankee RA, Grumet FC, Rogentine GN (1969) The selection of compatible platelet donors for refractory patients by lymphocyte HL-A typing. N Engl J Med 281: 1208
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This work was supported by the Deutsche Forschungsgemeinschaft (Mu 277/9-4)
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Küenzlen, E., Bauer, J., Bertram, U. et al. Fatal outcome of acute thrombocytopenic purpura associated with a viral infection in an 11-year-old child. Blut 48, 363–367 (1984). https://doi.org/10.1007/BF00319964
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DOI: https://doi.org/10.1007/BF00319964