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Lack of correlation between two markers of lymphocyte differentiation: 5′ nucleotidase activity and T lymphocyte colony formation

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Summary

Ecto 5′ nucleotidase (5′ NT) activity and T lymphocyte colony formation (TLCF) are both reputed to be markers for lymphocyte maturation. In order to determine whether these two expressions of lymphocyte activity are related, we compared 5′ NT activity with the TLC forming capacity of mononuclear cells from three study groups: normal adults, cord blood, and patients with immunodeficiencies. Despite individual examples of correlation between these two measurements, there was poor overall correlation in any of the groups studied. Although both measurements may reflect maturation of certain cellular activities, these are unlikely to be related.

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Authors and Affiliations

  1. Department of Pediatrics, University of Tennessee Center for the Health Sciences, 38163, Memphis, Tennessee, USA

    L. A. Freeman & H. G. Herrod

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  1. L. A. Freeman
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  2. H. G. Herrod
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Freeman, L.A., Herrod, H.G. Lack of correlation between two markers of lymphocyte differentiation: 5′ nucleotidase activity and T lymphocyte colony formation. Blut 49, 389–393 (1984). https://doi.org/10.1007/BF00319887

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  • DOI: https://doi.org/10.1007/BF00319887

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