References
Abo T, Balch CM (1981) A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 127: 1024
Bonnard GD, West WH (1979) Cell-mediated cytotoxicity in humans. A critical review of experimental models and clinically oriented studies. In: Herberman RB, McIntire KR (eds) Immunodiagnosis of Cancer 2. Marcel Dekker Publishers, New York: 1032–1105
Breard JM, Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1980) A monoclonal antibody reactive with human peripheral monocytes. J Immunol Immunopathol 18: 145
Buckley RH, Gilbertsen RB, Schiff RI, Ferreira E, Sanal SO, Waldmann TA (1976) Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect. J Clin Invest 58: 130
Cooper MD, Lawton AR, Miescher PA, Mueller-Eberhard HJ (1979) Immune deficiency. Springer, Berlin Heidelberg New York
DeBruin HG, Astaldi A, Leupers T, van de Griend RJ, Dooren LJ, Schellekens PTA, Tanke HJ, Roos M, Vossen JM (1981) T-lymphocyte characteristics in bone marrow transplanted patients. J Immunol 127: 244
DeWaeke M, Thielemans C, Van Camp BKG (1981) Characterization of immunoregulatory T cells in EBV-induced infections mononucleosis by monoclonal antibodies. N Engl J Med 304: 460
Foon KA, Schroff RW, Gale RP (1982) Surface markers on leukemia and lymphoma cells: Recent advances. Blood 60: 1
Grossi CE, Cadoni A, Zicca A, Leprini A, Ferrarini A (1982) Large granular lymphocytes in human peripheral blood: Ultrastructural and cytochemical characterization of the granules. Blood 59: 277
Herberman RB, Timonen T, Reynolds C, Ortaldo JR (1980) Characteristics of NK cells. In: Herberman RB (ed) Natural cell-mediated cytotoxicity against tumors. Academic Press, New York, p 89
Hersey P, Edwards A, Edwards J, Adams E, Milton GW, Nelson DS (1975) Specificity of cell-mediated cytotoxicity against human melanoma lines. Evedence for “non-specific” killing by activated T-cells. Int J Cancer 16: 173
Hitzig WH, Dooren LJ, Vossen JM (1979) Severe combined immunodeficiency disease. Cooper MD, Lawton AR, Miescher PA, Mueller-Eberhard HJ (eds) Immune Deficiency. Springer, Berlin Heidelberg New York, p 49
Janossy G, Tidman N, Papageorgiou ES, Kung PC, Goldstein G (1981) Distribution of T lymphocyte subsets in the human bone marrow and thymus: An analysis with monoclonal antibodies. J Immunol 126: 1608
Jondal M, Pross H (1975) Surface markers on B and T lymphocytes. VI. Cytotoxicity against cell lines as a functional marker of lymphocyte subpopulations. Int J Cancer 15: 596
Kaplan S, Callewaert DM (1978) Expression of human T-lymphocyte antigens by natural killer cells. J Natl Cancer Inst 60: 961
Kasai M, Iwamori M, Nagai K, Okumura K, Tada T (1980) A glycolipid on the surface of mouse natural killer cells. Eur J Immunol 10: 175
Kay HD, Bonnard GD, West WH, Herberman RB (1977) A functional comparison of human Fc receptor-bearing lymphocytes active in natural cytotoxicity and antibody-dependent cellular cytotoxicity. J Immunol 118: 2058
Koren HS, Amos DB, Buckley RB (1978) Natural killing in immunodeficient patients. J Immunol 120: 796
Kung P, Goldstein G (1981) Functional and developmental compartments of human T lymphocytes. Vox Sang 39: 121
Lipinski M, Virelizier JL, Tursz T, Griscelli C (1980) Natural killer and killer cell activities in patients with primary immunodeficiencies or defects in immune interferon production. Eur J Immunol 10: 246
Lohmann-Matthes ML, Domzig W, Roder J (1979) Promonocytes have the functional characteristics of natural killer cells. J Immunol 123: 1993
Lohmeier J, Rieber P, Feucht H, Johnson J, Hadam M, Riethmüller G (1981) A subset of human NK cells isolated and characterized by monoclonal antibodies. Eur J Immunol 11: 937
Ortaldo JR, Sharrow SO, Timonen T, Herberman RB (1981) Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. J Immunol 127: 2401
Peter HH, Bartholomäus C, Meyer zu Schwabedissen H, et al. (1980) Klinische und immunologische Befunde bei Patienten mit variablem Immundefektsyndrom (CVID). Verh Dtsch Ges Inn Med 86: 1458
Peter HH, Dallügge H, Zawatzky R, Euler S, Leibold W, Kirchner H (1980) Human peripheral Null lymphocytes. II. Producers of type-1 interferon upon stimulation with tumor cells, Herpes simplex virus and Corynebacterium parvum. Eur J Immunol 10: 547
Peter HH, Gendvilis S, Lange B, Serbin A, Euler S, Stangel W, Avenarius HJ, Deicher H (1979) Natural killing (NK) in hematopoietic disorders and immunodeficiency syndromes: evidence for the bone marrow dependency of human NK effector cells. Immunobiology 156: 206 (Abstract)
Peter HH, Kalden JR, Seeland P, Diehl V, Eckert G (1975) Humoral and cellular immune reactions in vitro against allogeneic and autologous melanoma cells. Clin Exp Immunol 20: 193
Peter HH, Nitschmann K, Krapf F, Siewertsen HC, Schmidt P, Leibold W (1979) Significance of spontaneous lymphocyte-mediated cytotoxicity (SCMC) in Cancer patients and control persons. In: Flad HD, Herfahrth C, Betzeler M (eds) Immunodiagnosis and Immunotherapy of malignent tumors. Springer, Berlin Heidelberg New York
Peter HH, Pavie-Fischer J, Fridman WH, Aubert C, Cesarini JP, Roubin R, Kourilsky FM (1975) Cell-mediated cytotoxicity in vitro of human lymphocytes against a tissue culture melanoma cell line (IGR3). J Immunol 115: 539
Peter HH, Rieger CR, Gendvilis S, Eckert G, Pichler WJ, Stangel W (1982) Spontaneous cell-mediated cytotoxicity (SCMC) in patients with myelodysplastic disorders and immunodeficiency syndromes. In: Serrou B, Rosenfeld C, Daniels J (eds) Current concepts in human immunology and cancer immunomodulation. Elsevier/North-Holland Publ, Amsterdam New York Oxford, p 341
Peter HH, Friedrich W, Dopfer R, Müller W, Kortmann C, Pichler WJ, Heinz F, Rieger CHL (1983) NK cell function in severe combined immunodeficiency (SCID): Evidence of a common T and NK cell defect in some but not all SCIDs. (submitted for publication)
Porzsolt F, Heimpel H (1982) Impaired immune functions in patients with preleukemia. Blut 45: 243
Pross HF, Baines MG (1976) Spontaneous human lymphocyte mediated cytotoxicity against tumor target cells. I. The effect of malignant disease. Int J Cancer 18: 593
Pross HT, Baines MG (1977) Spontaneous human lymphocyte mediated cytotoxicity against tumor target cells. VI. A brief review. Cancer Immunol Immunother 3: 75
Pross HT, Gupta S, Good RA, Baines MG (1978) Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. VII. The effect of immunodeficiency disease. Cell Immunol 43: 160
Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF (1980) Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci USA 77: 1588
Roder JC, Haliotis T, Klein M et al. (1980) A new disorder in humans involving NK cells. Nature 284: 553
Rumpold H, Kraft D, Obexer G, Böck G, Gebhart W (1982) A monoclonal antibody against a surface antigen showed by human large granular lymphocytes and granulocytes. J Immunol 129: 1024
Schmidt P, Peter HH, Kalden JR, Avenarius HJ, Bodenstein H (1978) Effektorfunktionen akuter Leukämiezellen in “spontanen” (SCMC) und Antikörper-abhängigen zellulären Zytotoxizitätstesten (ADCC). Klin Wochenschr 56: 953
Takaku S, Takaku F (1981) Natural killer cell activity and preleukemia. Lancet II: 1178
Takasugi M, Mickey RM, Terasaky PI (1973) Reactivity of lymphocytes from normal persons on cultured tumor cells. Cancer Res 33: 2898
Timonen T, Ortaldo JR, Herberman RB (1981) Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J Exp Med 153: 599
Timonen T, Saksela E, Virtanen I, Cantell K (1980) Natural killer cells are responsible for the interferon production induced in human lymphocytes by tumor cell contact. Eur J Immunol 10: 422
Tursz T, Dokhelar ML, Lipinski M, Amiel JL (1982) Low natural killer cell activity in patients with malignant lymphoma. Cancer: 50: 2333
West WH, Cannon GB, Kay HD, Bonnard GD, Herberman RB (1977) Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: Characterization of effector cells. J Immunol 118: 355
WHO Report Immunodeficiency (1979) Clin Immunol Immunopathol 13: 296
Zarling JM, Kung PC (1980) Monoclonal antibodies which distinguish between human NK cell and cytotoxic T lymphocytes. Nature 288: 394
Ziegler HW, Kay NE, Zarling JM (1981) Deficiency of natural killer cell activity in patients with chronic lymphocytic leukemia. Int J Cancer 27: 231
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Peter, H.H. The origin of human NK cells an ontogenic model derived from studies in patients with immunodeficiencies. Blut 46, 239–248 (1983). https://doi.org/10.1007/BF00319864
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DOI: https://doi.org/10.1007/BF00319864