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Ex vivo elimination of neoplastic T-cells from human marrow using an anti-Mr 41,000 protein immunotoxin: Potentiation by ASTA Z 7557

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Summary

ASTA Z 7557 potentiated the ex vivo efficiency of a T-cell directed immunotoxin containing pokeweed antiviral protein (PAP). We used an immunotoxin of pan-T monoclonal antibody 3-Al directed against p41 antigen expressed both on normal and leukemic T-cells. Treatment with 3Al-PAP in combination with ASTA Z 7557 produced 7–8 logs elimination of target lymphoblastic leukemia cells. Our data suggest that this new strategy shows potential for more effective ex vivo marrow purging in autologous marrow transplantation for acute lymphoblastic leukemia.

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Authors and Affiliations

  1. Department of Therapeutic Radiology, University of Minnesota Medical School, 420 Delaware Street, Box 367, 55455, Minneapolis, Minnesota, USA

    F. M. Uckun

  2. Department of Biochemistry, University of Kansas, USA

    S. Ramakrishnan & L. L. Houston

Authors
  1. F. M. Uckun
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  2. S. Ramakrishnan
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  3. L. L. Houston
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Uckun, F.M., Ramakrishnan, S. & Houston, L.L. Ex vivo elimination of neoplastic T-cells from human marrow using an anti-Mr 41,000 protein immunotoxin: Potentiation by ASTA Z 7557. Blut 50, 19–23 (1985). https://doi.org/10.1007/BF00319765

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  • DOI: https://doi.org/10.1007/BF00319765

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