Magnesium deficiency as a cause of acute intractable seizures


Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are presented which emphasize the importance of recognizing hypomagnesaemia in patients with acute intractable seizures.

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  1. 1.

    Anderson WW, Lewis DV, Swartzwelder HS, Wilson WA (1986) Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res 398:215–219

    Google Scholar 

  2. 2.

    Avoli M, Louvel J, Pumain R, Olivier A (1987) Seizure-like discharges induced by lowering [Mg 2+]0 in the human epileptogenic neocortex maintained in vitro. Brain Res 417:199–203

    Google Scholar 

  3. 3.

    Dyckner T, Wester PO (1982) Magnesium deficiency. Guidelines for diagnosis and substitution therapy. Acta Med Scand 661 [Suppl]:37–41

    Google Scholar 

  4. 4.

    Fishman RA (1965) Neurological aspects of magnesium metabolism. Arch Neurol 12:562–568

    Google Scholar 

  5. 5.

    Flink EB (1981) Magnesium deficiency. Etiology and clinical spectrum. Acta Med Scand 647 [Suppl]:125–137

    Google Scholar 

  6. 6.

    Hanna S, Harrison M, MacIntyre I, Fraser R (1960) The syndrome of magnesium deficiency in man. Lancet II:172–176

    Google Scholar 

  7. 7.

    Heaton FW, Pyrah LN, Beresford CC, Bryson RW, Martin DF (1962) Hypomagnesemia in chronic alcoholism. Lancet II:802–805

    Google Scholar 

  8. 8.

    Hirschfelder AD, Haury VG (1934) Clinical manifestations of high and low plasma magnesium. JAMA 102:1138–1141

    Google Scholar 

  9. 9.

    Jackson CE, Meier DW (1968) Routine serum magnesium analysis. Correlation with clinical state in 5,100 patients. Ann Intern Med 69:743–748

    Google Scholar 

  10. 10.

    Kato N, Higuchi T, Friesen HG, Wada JA (1983) Changes of immunoreactive somatostatin and β-endorphin content in rat brain after amygdaloid kindling. Life Sci 32:2415–2422

    Google Scholar 

  11. 11.

    Leaver DD, Parkinson GB, Schneider KM (1987) Neurological consequences of magnesium deficiency: correlations with epilepsy. Clin Exp Pharmacol Physiol 14:361–370

    Google Scholar 

  12. 12.

    Mody I, Lambert JDC, Heinemann U (1987) Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J Neurophysiol 57:869–888

    Google Scholar 

  13. 13.

    Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462–465

    Google Scholar 

  14. 14.

    Paymaster NJ (1976) Magnesium metabolism: a brief review. Ann R Coll Surg Engl 58:309–314

    Google Scholar 

  15. 15.

    Pittman Q, Siggins G (1981) Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro. Brain Res 221:402–408

    Google Scholar 

  16. 16.

    Pritchard JA, Pritchard SA (1975) Standardized treatment of 154 consecutive cases of eclampsia. Am J Obstet Gynecol 123:543–552

    Google Scholar 

  17. 17.

    Ryzen E, Elbaum N, Singer FR, Rude RK (1985) Parenteral magnesium tolerance testing in the evaluation of magnesium deficiency. Magnesium 4:137–147

    Google Scholar 

  18. 18.

    Sargent WQ, Simpson JR, Beard JD (1974) The effects of acute and chronic ethanol administration on divalent cation excretion. J Pharmacol Exp Ther 190:507–514

    Google Scholar 

  19. 19.

    Suter C, Klingman WO (1955) Neurologic manifestations of magnesium depletion states. Neurology 5:691–699

    Google Scholar 

  20. 20.

    Vallee BL, Wacker WEC, Ulmer DD (1960) The magnesium deficiency tetany syndrome in man. N Engl J Med 262:155–161

    Google Scholar 

  21. 21.

    Wacker WEC, Parisi AF (1968) Magnesium metabolism. N Engl J Med 278:658–663

    Google Scholar 

  22. 22.

    Walther H, Lambert JDC, Jones RSG, Heinemann U, Hamon B (1986) Epileptiform activity in combined slices of the hippocampus, subiculum and enthorinal cortex during perfusion with low magnesium medium. Neurosci Lett 69:156–161

    Google Scholar 

  23. 23.

    Woodbury J, Lyons K, Carretta R, Hahn A, Sullivan JF (1968) Cerebrospinal fluid and serum levels of magnesium, zinc and calcium in man. Neurology 18:700–705

    Google Scholar 

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Correspondence to D. Nuytten.

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Nuytten, D., Van Hees, J., Meulemans, A. et al. Magnesium deficiency as a cause of acute intractable seizures. J Neurol 238, 262–264 (1991).

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Key words

  • Epilepsy
  • Hypomagnesaemia
  • Somatostatin