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A morphometric study of sub-cellular organization in mouse mammary cancers and normal lactating tissue

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Summary

Four normal lactating glands of Mice and nine mammary cancers have been studied by quantitative electron microscopy.

Normal lactating cells are characterized by a high organelle development: the mitochondria occupy 11.2% and the Golgi apparatus 7.4% of the cytoplasm (without lipid droplets). The ergastoplasm attains a surface of 4.7 square micron per cubic micron of cytoplasm.

All mammary cancers examined had a lower organelle development than normal lactating gland cells and this independently from the fact whether the tumour cells were secreting or not.

A relationship between the number of virus particles in the section area and the degree of organelle development does not exist.

Résumé

L'étude quantitative au microscope électronique de quatre glandes mammaires lactantes de souris et de neuf cancer mammaires a été effectuée.

Les cellules lactantes normales sont caractérisées par un grand développement des organites cytoplasmiques: les mitochondries occupent 11,2% et l'appareil de Golgi 7,4% du cytoplasme (gouttelettes lipidiques exclues); 'ergastoplasme atteind une surface de 4,7 microns carrés par micron cubique de cytoplasme.

Tous les cancers mammaires examinés, que les cellules tumorales soient sécrétantes ou non, ont des organites cellulaires moins développés que les cellules lactantes normales.

Il n'existe pas de relation entre le nombre de particules virales dans une section donnée et le degré de développement des organites cellulaires.

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Authors and Affiliations

  1. Chaire de Médecine Expérimentale du Collège de France, Paris

    K. H. Hollmann

  2. Laboratoire de Microscopie Electronique à l'Hôpital Broussais, France

    K. H. Hollmann

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  1. K. H. Hollmann
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Hollmann, K.H. A morphometric study of sub-cellular organization in mouse mammary cancers and normal lactating tissue. Z. Zellforsch. 87, 266–277 (1968). https://doi.org/10.1007/BF00319724

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  • DOI: https://doi.org/10.1007/BF00319724

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