Summary
The peripolar cell is a unique cell type in the mammalian glomerulus. Peripolar cells are said to be identifiable during light microscopy by their cytoplasmic granules and by their position at the vascular pole; and during scanning electron microscopy by their distinctive surface morphology. We used both techniques to count peripolar cells in 6 normal rat kidneys. Scanning microscopy revealed that 55(±5)% of glomeruli contained at least one peripolar cell whereas light microscopy revealed granulated peripolar cells in only 4(±2)% of glomeruli. Vascular poles which contained peripolar cells previously identified by scanning were then examined by light and by transmission electron microscopy. Serial sections through these peripolar cells demonstrated the absence of cytoplasmic granules. Our observations suggest that the majority of peripolar cells in the rat contain no granules.
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Gall JAM, Alcorn D, Butkus A, Coghlan JP, Ryan GB (1986) Distribution of glomerular peripolar cells in different mammalian species. Cell Tissue Res 244: 203–208
Gardiner DS, Lindop GBM (1985) The granular peripolar cell of the human glomerulus and its relationship to the renin-angiotensin system. Histopathology 9: 675–685
Gardiner DS, Lindop GBM (1992) The glomerular peripolar cell: an immunohistochemical study. APMIS 100: 107–115
Gardiner DS, More IAR, Lindop GBM (1986) The granular peripolar cell of the human glomerulus; an ultrastructural study. J Anat 146: 31–43
Gardiner DS, Downie I, Gibson IW, More IAR, Lindop GBM (1991) The glomerular peripolar cell: a review. Histol Histopathol 6: 567–573
Gibson IW, More IAR, Lindop GBM (1989) A scanning electron microscopic study of the peripolar cell of the rat renal glomerulus. Cell Tissue Res 257: 201–206
Kelly G, Downie I, Gardiner DS, More IAR, Lindop GBM (1990) The peripolar cell: a distinctive cell type in the mammalian glomerulus. Morphological evidence from a study of sheep. J Anat 168: 217–227
Ryan GB, Coghlan JP, Scoggins BA (1979) The granulated peripolar epithelial cell: a potential secretory component of the renal juxtaglomerular complex. Nature 227: 655–656
Taugner R, Buhrle CP, Nobiling R, Kirschke H (1985) Coexistence of renin and cathepsin B in epithelioid cell secretory granules. Histochemistry 83: 103–108
Trahair JF, Ryan GB (1989) Immunohistochemical identification of plasma proteins in cytoplasmic granules of peripolar cells in sheep. J Anat 160: 109–115
Wang Y, Bass PS, Higgins M, Thomas JH, Davies DR (1989) Endocytosis of horseradish peroxidase-poly-lysine conjugate by glomerular epithelial cells: an in vivo study. J Pathol 159: 159–168
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Downie, I., Gardiner, D.S., Downie, T.T. et al. Non-granulated peripolar cells exist in the rat glomerulus. Cell Tissue Res 268, 567–570 (1992). https://doi.org/10.1007/BF00319164
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DOI: https://doi.org/10.1007/BF00319164