Summary
The nonparenchymal portion of the liver of parasitic adult lampreys (Petromyzon marinus L.) consists of endothelial, Kupffer, fibroblast-like, fat-storing, and granulated cells. The fenestrae of endothelial cells are not organized into sieve plates but are of highly variable size and distribution. The dimension of large molccular size. Small numbers of Kupffer cells possess many features of these cells observed in other vertebrates but they do not have worm-like bodies and endogenous peroxidase activity. They are involved in erythrophagocytosis and perhaps the ingestion of other foreign material but they do not store iron. Fat-storing and fibroblast-like cells share many morphological features and may be different expressions of the same cell type. These perisinusoidal cells are rich in organelles suggesting protein synthesis but the fibroblast-like cells lack fat droplets. A cell with a large Golgi apparatus and associated cytoplasmic granules resembles the pit cell described in the liver of a few other vertebrates. The morphology of nonparenchymal cells of the liver in parasitic adult lampreys does not reflect the absence of bile ducts in this organism.
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References
Agius C, Agbede SA (1984) An electron microscopical study on the genesis of lipofuscin, melanin and haemosiderin in the haemopoietic tissues of fish. J Fish Biol 24:471–488
Agius C, Roberts RJ (1981) Effects of starvation on the melanomacrophage centres of fish. J Fish Biol 19:161–169
Bankston PW, Pino MR (1980) The development of the sinusoids of fetal rat liver: morphology of endothelial cells, Kupffer cells, and the transmural migration of blood cells into the sinusoids. Am J Anat 159:1–15
Ferri S (1981) Ultrastructural study of the pit cell in a freshwater teleost liver. Arch Anat Microsc Morphol Exp 70:109–115
Fujita H, Tamarv T, Miyagawa J (1980) Fine structural characteristics of the hepatic sinusoidal walls of the goldfish (Carassius auratus). Arch Histol Jpn 43:265–273
Ito T, Shibasaki S (1968) Electron microscopic study on the hepatic sinusoidal wall and the fat-storing cells in the normal human liver. Arch Histol Jpn 29:134–192
Ito T, Watanabe A, Takahashi Y (1962) Histologische und cytologische Untersuchungen der Leber bei Fisch und Cyclostoma, nebst Bemerkungen über die Fettspeicherungszellen. Arch Histol Jpn 22:429–463
Jones EA (1983) Hepatic sinusoidal cells: new insights and controversies. Hepatology 3:259–266
Kaneda K, Wake K (1983) Distribution and morphological characteristics of the pit cells in the liver of the rat. Cell Tissue Res 233:485–505
Kent G, Gay S, Inouye T, Baku R, Minick OT, Popper H (1976) Vitamin A-containing lipocytes and formation of type III collagen in liver injury PNAS 73:3719–3722
Knook DL, Sleyster CH (1976) Separations of Kupffer and endothelial cells of the rat liver by centrifugal elutration. Exp Cell Res 99:444–449
Langille RM, Youson JH (1984) Morphology of the intestine of prefeeding and feeding adult lampreys, Petromyzon marinus L.: the mucosa of the diverticulum, anterior intestine, and the transition zone. J Morphol 182:39–61
Millonig G (1961) Advantages of a phosphate buffer for OsO4. J Appl Phys 32:1637
Motta PM (1984) The three-dimensional microanatomy of the liver. Arch Histol Jpn 47:1–30
Nopanitaya W, Aghajanian J, Grisham JW, Carson JL (1979) An ultrastructural study on a new type of hepatic perisinusoidal cell in fish. Cell Tissue Res 198:35–42
Peck WD, Sidon EW, Youson JH, Fisher MM (1979) Fine structure of the liver in the larval lamprey, Petromyzon marinus L.; hepatocytes and sinusoids. Am J Anat 156:231–250
Percy R, Potter IC (1981) Further observations on the development and destruction of lamprey blood cells. J Zool 193:239–251
Shin YC (1977) Some observations on the fine structure of lamprey liver as revealed by electron microscopy. Okaj Fol Anat Jpn 54:25–60
Sidon EW, Youson JH (1983) Morphological changes in the liver of the sea lamprey, Petromyzon marinus L., during metamorphosis: I Atresia of the bile ducts. J Morphol 177:109–124
Takahashi Y, Tsubovchi H, Kobayashi K (1978) Effects of vitamin A administration upon Ito's fat-storing cells of the liver in the carp. Arch Histol Jpn 41:339–349
Tanuma Y, Ito T (1980) Electron microscopic study on the sinusoidal wall of the liver of the crucian, Carassius carassius, with special remarks on the fat-storing cell (FSC). Arch Histol Jpn 43:241–263
Tanuma Y, Ohata M, Ito T (1982) Electron microscopic study on the sinusoidal wall of the liver in the flatfish, Kareius bicoloratus: demonstration of numerous desmosomes along the sinusoidal wall. Arch Histol Jpn 45:453–472
Wake K (1971) “Sternzellen” in the liver; perisinusoidal cells with special reference to storage of vitamin A. Am J Anat 132:429–462
Wake K (1982) The Sternzellen of Von Kupffer — after 106 years. In: Knook DL, Wisse E (eds) Sinusoidal liver cells, Elsevier Biomedical Press, Amsterdam, pp 1–12
Widmann JJ, Cotran RS, Fahimi HD (1972) Mononuclear phagocytes (Kupffer cells) and endothelial cells. Identification of two functional cell types in rat liver sinusoids by endogenous peroxidase activity. J Cell Biol 52:159–170
Wisse E (1970) An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. J Ultrastruct Res 31:125–150
Wisse E (1972) An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J Ultrastruct Res 38:528–562
Wisse E (1974) Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells. J Ultrastruct Res 46:393–426
Wisse E, Knook DL (1979) The investigation of sinusoidal cells: a new approach to the study of liver function. In: Popper H, Schaffner F (eds) Progress in liver diseases, Vol 6, Grune and Stratton, New York, pp 153–171
Wisse E, Van'T Noordende JM, Van Der Meulen J, Daems WTh (1976) The pit cell: description of a new type of cell occurring in rat liver sinusoid and peripheral blood. Cell Tissue Res 173:423–435
Youson JH (1981a) The alimentary canal. In: Hardisty MW, Potter IC (eds) The biology of lampreys, Vol 3, Academic Press, London, pp 95–189
Youson JH (1981b) The liver. In: Hardisty MW, Potter IC (eds) The biology of lamprys, Vol 3, Academic Press, London. pp 263–332
Youson JH, Sidon EW (1978) Lamprey biliary atresia: first model system for the human condition? Experientia (Basel) 34:1084–1086
Youson JH, Sargent PA, Sidon EW (1983a) Iron loading in the liver of parasitic adult lampreys, Petromyzon marinus L. Am J Anat 168:37–49
Youson JH, Peek WD, Shivers RR (1983b) Gap junctions in the liver of parasitic adult lampreys, Petromyzon marinus L. Anat Embryol 167:379–389
Youson JH, Sidon EW, Peek WD, Shivers RR (1985) Ultrastructure of the hepatocytes in a vertebrate liver without bile ducts. J Anat 140:143–158
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Youson, J.H., Yamamoto, K. & Shivers, R.R. Nonparenchymal liver cells in a vertebrate without bile ducts. Anat Embryol 172, 89–96 (1985). https://doi.org/10.1007/BF00318947
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DOI: https://doi.org/10.1007/BF00318947