Abstract
A close topographical association between neuroepithelial bodies and immune cells is occasionally observed in the lungs of various neonatal mammalian species. The immune cells concerned are mast cells and neutrophil or eosinophil granulocytes. In the lungs of newborn puppies having undergone left lung autotransplantation, mast cells are particularly numerous in the airway mucosa of both right and left lungs and their association with neuroepithelial bodies is highly significant. Several of the substances known to be synthesized by the neuroepithelial bodies have a chemoattractive effect on immune cells. Thus, our observations indicate that intrapulmonary neuroepithelial bodies contribute to the local immune response.
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References
Achmed TH, Rao GS (1992) Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers. Biochem Biophys Res Commun 189:994–1000
Aguyo SM, King TE, Waldron JA, Sherritt KM, Kane MA, Miller YE (1990) Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma. J Clin Invest 86:838–844
Bousbaa H, Fleury-Feith J (1991) Effects of a long-standing challenge on pulmonary neuroendocrine cells of actively sensitized guinea pigs. Am Rev Respir Dis 144:714–717
Bousbaa H, Poron F, Fleury-Feith J (1994) Changes in chromogranin A-immunoreactive guinea-pig pulmonary neuroendocrine cells after sensitization and challenge with ovalbumin. Cell Tissue Res 275:195–199
Chabaud O, Lissitzky S (1977) Thyrotropin-specific binding to human peripheral blood monocytes and polymorphonuclear leukocytes. Mol Cell Endocrinol 7:79–87
Cho T, Chan W, Cutz E (1989) Distribution and frequency of neuroepithelial bodies in postnatal rabbit lung: quantitative study with monoclonal antibody against serotonin. Cell Tissue Res 255:353–362
Del Rio M, De la Fuente M (1994) Chemoattractant capacity of bombesin, gastrin-releasing peptide and neuromedin C is mediated through PKC activation in murine peritoneal leucocytes. Regul Pept 49:185–193
Hoyt RF, McNelly NA, McDowell EM, Sorokin SP (1991) Neuroepithelial bodies stimulate proliferation of airway epithelium in fetal hamster lung. Am J Physiol 260:L234-L240
Johnson NF, Wagner JC, Wills HA (1980) Endocrine cell proliferation in the rat lung following asbestos inhalation. Lung 158:221–228
Keith IM, Will JA (1982) Dynamics of the neuroendocrine cell-regulatory peptide system in the lung. Exp Lung Res 3:387–402
Lauweryns JM, Cokelaere M, Theunynck P (1972) Neuroepithelial bodies in the respiratory mucosa of various mammals. A light optical, histochemical and ultrastructural investigation. Z Zellforsch 135:569–592
Lauweryns JM, Cokelaere M, Deleersnyder M, Liebens M (1977) Intrapulmonary neuroepithelial bodies in newborn rabbits. Influence of hypoxia, hyperoxia, hypercapnia, nicotine, reserpine, L-DOPA and 5-HTP. Cell Tissue Res 182:425–440
Lauweryns JM, Bock V de, Guelinckx P, Decramer M (1983) Effects of unilateral hypoxia on neuroepithelial bodies in rabbit lungs. J Appl Physiol 55:1665–1668
Manley HC, Haynes LW (1989) Eosinophil chemotactic response to rat CGRP-1 is increased after exposure to trypsin or guineapig lung particulate fraction. Neuropeptides 13:29–34
Marchevsky AM, Keller S, Fogel JR, Kleinerman J (1984) Quantitative studies of argyrophilic APUD cells in airways. III The effects of sensitization and anaphylactic shock. Am Rev Respir Dis 129:477–480
Sacerdote P, Bianchi M, Panerai AE (1990) Human monocyte chemotactic activity of calcitonin and somatostatin related peptides: modulation by chronic peptide treatment. J Clin Endocrinol Metab 70:141–148
Scheuermann DW, Adriaensen D, Timmermans JP, De Groodt-Lasseel (1992) Comparative histological overview of the chemical coding of the pulmonary neuroepithelial endocrine system in health and disease. Eur J Morphol 30:101–112
Seldeslagh KA, Lauweryns JM (1993) Endothelin in normal lung tissue of newborn mammals: immunocytochemical distribution and colocalization with serotonin and calcitonin gene related peptide. J Histochem Cytochem 41:1495–1502
Sorokin SP, Hoyt RF (1989) Neuroepithelial bodies and solitary small-granule cells. In: Massaro D (ed) Lung biology in health and disease, vol 41. Lung cell biology. Dekker, New York, pp 191–344
Sunday ME, Hua J, Dai HB, Nusrat A, Torday JS (1990) Bombesin increases fetal lung growth and maturation in utero and in organ culture. Am J Respir Cell Mol Biol 3:199–205
van Lommel A, Lauweryns JM (1993) Neuroepithelial bodies in the fawn hooded rat lung: morphological and neuroanatomical evidence for a sensory innervation. J Anat 183:553–566
van Lommel A, Lauweryns JM, De Leyn P, Wouters P, Schreinemakers H, Lerut T (1995) Pulmonary neuroepithelial bodies in neonatal and adult dogs: histochemistry, ultrastructure and effects of unilateral hilar lung denervation. Lung 173:13–23
Youngson C, Nurse C, Yeger H, Cutz E (1993) Oxygen sensing in airway chemoreceptors. Nature 365:153–155
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This investigation was supported by a grant from the Fonds voor Geneeskundig Wetenschappelijk Onderzoek (FGWO-NFWO), Belgium
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van Lommel, A., van den Steen, P. & Lauweryns, J.M. Association of immune cells with neuroepithelial bodies in the lungs of neonatal dogs, cats and hamsters. Cell Tissue Res 282, 519–522 (1995). https://doi.org/10.1007/BF00318884
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DOI: https://doi.org/10.1007/BF00318884